Document Detail


Anti-inflammatory activity of oleanolic acid in rats and mice.
MedLine Citation:
PMID:  1359067     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Oleanolic acid displayed anti-inflammatory activity in carrageenan and dextran-induced oedema in rats. It elicited marked anti-arthritic action in adjuvant-induced polyarthritis in rats and mice and in formaldehyde-induced arthritis in rats. Oleanolic acid checked the inflammation-induced increased serum transaminase levels. It reduced exudate volume and inhibited leucocyte infiltration in carrageenan-induced pleurisy in rats. It is devoid of any analgesic, antipyretic or ulcerogenic action. Oleanolic acid did not affect the parturition time in pregnant rats or castor oil-induced diarrhoea in rats. Oral LD50 was found to be greater than 2 g kg-1 in mice and rats.
Authors:
G B Singh; S Singh; S Bani; B D Gupta; S K Banerjee
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of pharmacy and pharmacology     Volume:  44     ISSN:  0022-3573     ISO Abbreviation:  J. Pharm. Pharmacol.     Publication Date:  1992 May 
Date Detail:
Created Date:  1992-12-04     Completed Date:  1992-12-04     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0376363     Medline TA:  J Pharm Pharmacol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  456-8     Citation Subset:  IM    
Affiliation:
Pharmacology Department, Regional Research Laboratory, Jammu-Tawi, India.
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MeSH Terms
Descriptor/Qualifier:
Adrenalectomy
Animals
Anti-Inflammatory Agents
Anti-Inflammatory Agents, Non-Steroidal / pharmacology,  toxicity
Arthritis, Experimental / drug therapy
Behavior, Animal / drug effects
Carrageenan
Diarrhea / chemically induced,  prevention & control
Edema / chemically induced,  prevention & control
Female
Formaldehyde
Gossypium
Labor, Obstetric / drug effects
Male
Mice
Oleanolic Acid / pharmacology*,  toxicity
Pleurisy / chemically induced,  prevention & control
Pregnancy
Rats
Seeds / chemistry
Stomach Ulcer / chemically induced
Transaminases / blood
Chemical
Reg. No./Substance:
0/Anti-Inflammatory Agents; 0/Anti-Inflammatory Agents, Non-Steroidal; 50-00-0/Formaldehyde; 508-02-1/Oleanolic Acid; 9000-07-1/Carrageenan; EC 2.6.1.-/Transaminases

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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