Document Detail

Anti-inflammatory activity of lipoic acid in mice peritonitis model.
MedLine Citation:
PMID:  24147369     Owner:  NLM     Status:  In-Process    
This work aimed to investigate the effect of lipoic acid (LA) on sulfane sulfur (S*) level, infiltration of neutrophils and vascular permeability in a model of zymosan-induced peritonitis. The study showed that lipoic acid increased the sulfane sulfur level. Also, it decreased count of neutrophils and inhibition of intensity of early vascular permeability compared to the control group. These studies indicated that LA exhibits antiinflammatory activity. LA serves as a sulfane sulfur acceptor and releases sulfane sulfur in the form of hydrogen sulfide (H2S), which is probably responsible for its anti-inflammatory activity.
Małgorzata Zygmunt; Magdalena Dudek; Anna Bilska-Wilkosz; Marek Bednarski; Szczepan Mogilski; Joanna Knutelska; Jacek Sapa
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Acta poloniae pharmaceutica     Volume:  70     ISSN:  0001-6837     ISO Abbreviation:  Acta Pol Pharm     Publication Date:    2013 Sep-Oct
Date Detail:
Created Date:  2013-10-23     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  2985167R     Medline TA:  Acta Pol Pharm     Country:  Poland    
Other Details:
Languages:  eng     Pagination:  899-904     Citation Subset:  IM    
Department of Pharmacological Screening, Jagiellonian University Medical College, Medyczna 9 St., 30-688 Kraków, Poland.
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