Document Detail


Anti-inflammatory activity of the alkaloid bukittinggine from Sapium baccatum.
MedLine Citation:
PMID:  9741299     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The anti-inflammatory and related activities of bukittinggine were evaluated in comparison with reference drugs. The results obtained revealed that bukittinggine exhibited a significant inhibitory effect in carrageenin-induced hind paw edema and adjuvant-induced arthritis in rats. Its anti-inflammatory activity in both test models was comparable to that of acetylsalicylic acid. Bukittinggine also showed an inhibitory effect on the late proliferative phase of the inflammatory process in cotton pellet-induced granuloma formation in rats. In carrageenin-induced rat pleurisy, bukittinggine exhibited marked inhibitory activity on exudative formation, accumulation of leukocytes and on PGE2-like activity in the exudate. Furthermore bukittinggine could significantly reduce fever in yeast-induced hyperthermic rats and possessed analgesic activity comparable to that of acetylsalicylic acid when tested in acetic acid-induced writhing response in mice. However, bukittinggine exhibited only a weak effect in the tail-flick test when compared with morphine. It is likely that bukittinggine possesses a mechanism of anti-inflammatory, analgesic and antipyretic action similar to that of acetylsalicylic acid.
Authors:
A Panthong; D Kanjanapothi; Y Thitiponpunt; T Taesotikul; D Arbain
Related Documents :
7498269 - Interaction of 5-aminosalicylic acid with nitric oxide on rat aortic strips and human p...
17470369 - Differential effects of tannic acid on cisplatin induced nephrotoxicity in rats.
7488399 - Anti-inflammatory activity of croconazole, a broad-spectrum antimycotic agent, in the a...
18193099 - Gymnema sylvestre: a memoir.
1243029 - Suprofen, a potent antagonist of acetic acid-induced writhing in rats.
20412019 - Anti-human rhinovirus activity of raoulic acid from raoulia australis.
9630379 - Monounsaturated oils do not all have the same effect on plasma cholesterol.
20438849 - Initial stages of enamel erosion: an in situ atomic force microscopy study.
1394159 - Pesticides and non-hodgkin's lymphoma.
Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Planta medica     Volume:  64     ISSN:  0032-0943     ISO Abbreviation:  Planta Med.     Publication Date:  1998 Aug 
Date Detail:
Created Date:  1998-10-15     Completed Date:  1998-10-15     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0066751     Medline TA:  Planta Med     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  530-5     Citation Subset:  IM    
Affiliation:
Department of Pharmacology, Faculty of Medicine, Chiang Mai University, Thailand. apanthon@sd01.med.cmu.ac.th
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Abdominal Muscles / drug effects,  pathology,  physiology
Acetic Acid / toxicity
Alkaloids / chemistry,  isolation & purification,  pharmacology*
Analgesics, Non-Narcotic / chemistry,  isolation & purification,  pharmacology*
Animals
Anti-Inflammatory Agents, Non-Steroidal / chemistry,  isolation & purification,  pharmacology*
Arthritis, Experimental / drug therapy*
Aspirin / pharmacology
Carrageenan
Edema / chemically induced,  drug therapy*
Fever / drug therapy
Male
Mice
Morphine / pharmacology
Pain / drug therapy
Plants, Medicinal*
Rats
Rats, Sprague-Dawley
Chemical
Reg. No./Substance:
0/Alkaloids; 0/Analgesics, Non-Narcotic; 0/Anti-Inflammatory Agents, Non-Steroidal; 0/bukittinggine; 50-78-2/Aspirin; 57-27-2/Morphine; 64-19-7/Acetic Acid; 9000-07-1/Carrageenan

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Inhibitory effects of Angelica pubescens f. biserrata on 5-lipoxygenase and cyclooxygenase.
Next Document:  Ilex aquifolium: protection against enzymatic and non-enzymatic lipid peroxidation.