Document Detail

Anti-inflammatory activity of the alkaloid bukittinggine from Sapium baccatum.
MedLine Citation:
PMID:  9741299     Owner:  NLM     Status:  MEDLINE    
The anti-inflammatory and related activities of bukittinggine were evaluated in comparison with reference drugs. The results obtained revealed that bukittinggine exhibited a significant inhibitory effect in carrageenin-induced hind paw edema and adjuvant-induced arthritis in rats. Its anti-inflammatory activity in both test models was comparable to that of acetylsalicylic acid. Bukittinggine also showed an inhibitory effect on the late proliferative phase of the inflammatory process in cotton pellet-induced granuloma formation in rats. In carrageenin-induced rat pleurisy, bukittinggine exhibited marked inhibitory activity on exudative formation, accumulation of leukocytes and on PGE2-like activity in the exudate. Furthermore bukittinggine could significantly reduce fever in yeast-induced hyperthermic rats and possessed analgesic activity comparable to that of acetylsalicylic acid when tested in acetic acid-induced writhing response in mice. However, bukittinggine exhibited only a weak effect in the tail-flick test when compared with morphine. It is likely that bukittinggine possesses a mechanism of anti-inflammatory, analgesic and antipyretic action similar to that of acetylsalicylic acid.
A Panthong; D Kanjanapothi; Y Thitiponpunt; T Taesotikul; D Arbain
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Planta medica     Volume:  64     ISSN:  0032-0943     ISO Abbreviation:  Planta Med.     Publication Date:  1998 Aug 
Date Detail:
Created Date:  1998-10-15     Completed Date:  1998-10-15     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0066751     Medline TA:  Planta Med     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  530-5     Citation Subset:  IM    
Department of Pharmacology, Faculty of Medicine, Chiang Mai University, Thailand.
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MeSH Terms
Abdominal Muscles / drug effects,  pathology,  physiology
Acetic Acid / toxicity
Alkaloids / chemistry,  isolation & purification,  pharmacology*
Analgesics, Non-Narcotic / chemistry,  isolation & purification,  pharmacology*
Anti-Inflammatory Agents, Non-Steroidal / chemistry,  isolation & purification,  pharmacology*
Arthritis, Experimental / drug therapy*
Aspirin / pharmacology
Edema / chemically induced,  drug therapy*
Fever / drug therapy
Morphine / pharmacology
Pain / drug therapy
Plants, Medicinal*
Rats, Sprague-Dawley
Reg. No./Substance:
0/Alkaloids; 0/Analgesics, Non-Narcotic; 0/Anti-Inflammatory Agents, Non-Steroidal; 0/bukittinggine; 50-78-2/Aspirin; 57-27-2/Morphine; 64-19-7/Acetic Acid; 9000-07-1/Carrageenan

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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