| Anti-inflammatory activity of D-002: an active product isolated from beeswax. | |
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MedLine Citation:
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PMID: 9849648 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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D-002 is a natural mixture of high molecular weight alcohols isolated and purified from beeswax, which contains triacontanol among its main components. This study was undertaken to investigate the anti-inflammatory effects of D-002 administered by the oral route in two animal models commonly used in the pharmacological screening of anti-inflammatory drugs. D-002 administered orally to rats (100 and 200 mg/kg) produced a mild but significant reduction of exudate volume in carrageenan-induced pleuritic inflammation that was accompanied by a marked and significant decrease of leukotriene B4 (LTB4) levels in the exudate. D-002 (25, 50 and 200 mg/kg) also significantly diminished the granuloma weight in the cotton pellet granuloma in rats. In both cases, D-002 was less effective than indomethacin, which was used as an established anti-inflammatory reference drug. On the other hand, D-002 administered from 25-1000 mg/kg did not induce erosions or gastromucosal lesions in rats, which differs from results usually obtained with non steroidal anti-inflammatory drugs. These results indicate that D-002 is a mild anti-inflammatory agent without any ulcerogenic effect associated. The results suggest that these effects are probably not mediated through an inhibition of cyclooxygenase, but a reduction in LTB4 levels induced by D-002 could explain these results. |
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Authors:
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D Carbajal; V Molina; S Valdés; M L Arruzazabala; R Más; J Magraner |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Prostaglandins, leukotrienes, and essential fatty acids Volume: 59 ISSN: 0952-3278 ISO Abbreviation: Prostaglandins Leukot. Essent. Fatty Acids Publication Date: 1998 Oct |
Date Detail:
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Created Date: 1999-02-11 Completed Date: 1999-02-11 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 8802730 Medline TA: Prostaglandins Leukot Essent Fatty Acids Country: SCOTLAND |
Other Details:
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Languages: eng Pagination: 235-8 Citation Subset: IM |
Affiliation:
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Center of Natural Products National Center for Scientific Research, C. Habana, Cuba. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Oral Animals Anti-Inflammatory Agents / pharmacology*, therapeutic use Anti-Ulcer Agents / pharmacology, therapeutic use Carrageenan / pharmacology Fatty Alcohols / pharmacology*, therapeutic use Gastric Mucosa / drug effects Gossypium / metabolism Granuloma / chemically induced, drug therapy Indomethacin / pharmacology, therapeutic use Inflammation / drug therapy Pleurisy / chemically induced, drug therapy Rats Rats, Sprague-Dawley Waxes / chemistry* |
| Chemical | |
Reg. No./Substance:
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0/Anti-Inflammatory Agents; 0/Anti-Ulcer Agents; 0/D 002; 0/Fatty Alcohols; 0/Waxes; 53-86-1/Indomethacin; 8012-89-3/beeswax; 9000-07-1/Carrageenan |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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