| Anti-inflammatory activities of cucurbitacin E isolated from Citrullus lanatus var. citroides: Role of reactive nitrogen species and cyclooxygenase enzyme inhibition. | |
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MedLine Citation:
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PMID: 21871542 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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The in vivo and in vitro mechanistic anti-inflammatory actions of cucurbitacin E (CE) (Citrullus lanatus var. citroides) were examined. The results showed that LPS/INF-γ increased NO production in RAW264.7 macrophages, whereas L-NAME and CE curtailed it. CE did not reveal any cytotoxicity on RAW264.7 and WRL-68 cells. CE inhibited both COX enzymes with more selectivity toward COX-2. Intraperitoneal injection of CE significantly suppressed carrageenan-induced rat's paw edema. ORAC and FRAP assays showed that CE is not a potent ROS scavenger. It could be concluded that CE is potentially useful in treating inflammation through the inhibition of COX and RNS but not ROS. |
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Authors:
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Siddig Ibrahim Abdelwahab; Loiy Elsir Ahmed Hassan; Hasnah Mohd Sirat; Sakina M Ahmed Yagi; Waleed S Koko; Syam Mohan; Manal Mohamed Elhassan Taha; Syahida Ahmad; Cheah Shiau Chuen; Putri Narrima; Mohd Mustafa Rais |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-8-11 |
Journal Detail:
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Title: Fitoterapia Volume: - ISSN: 1873-6971 ISO Abbreviation: - Publication Date: 2011 Aug |
Date Detail:
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Created Date: 2011-8-29 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 16930290R Medline TA: Fitoterapia Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2011 Elsevier B.V. All rights reserved. |
Affiliation:
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Department of Pharmacy, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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