Document Detail

Anti-inflammatory action of diltiazem in patients with unstable angina.
MedLine Citation:
PMID:  16954457     Owner:  NLM     Status:  MEDLINE    
BACKGROUND AND AIMS: Plasma concentrations of anti-inflammatory cytokine interleukin 10 (IL10) have been shown to be decreased in patients with unstable angina (UA) suggesting that reduced concentrations of IL10 may favour plaque instability and the development of acute coronary syndromes. Diltiazem has been shown to exert beneficial effects in patients with acute coronary syndrome. However, the potential influence of diltiazem on the anti-inflammatory cytokine IL10 in patients with UA has not been investigated. This study was designed to find out the effects of diltiazem on IL10 in UA patients.
METHODS AND RESULTS: Thirty patients with UA were divided into two groups: group R and group D (n = 15). Group R was given routine pharmacotherapy for UA, and group D was given routine pharmacotherapy plus diltiazem. Plasma concentrations of IL10 in these groups were measured before the start of the treatment and 28 days after treatment. Plasma concentrations of IL10 in 15 normal subjects (group N) were also measured. Patients with UA had decreased concentrations of IL10 compared with normal group. Four weeks after treatment, plasma concentrations of IL10 significantly increased in group D compared with that before treatment, but the increase in IL10 values in group R was not significant.
CONCLUSIONS: These findings showed that concentrations of anti-inflammatory IL10 are considerably decreased in UA patients and diltiazem treatment leads to a significant increase in IL10 concentrations.
L Dubey; Z Hesong
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Postgraduate medical journal     Volume:  82     ISSN:  1469-0756     ISO Abbreviation:  Postgrad Med J     Publication Date:  2006 Sep 
Date Detail:
Created Date:  2006-09-06     Completed Date:  2006-12-14     Revised Date:  2013-06-07    
Medline Journal Info:
Nlm Unique ID:  0234135     Medline TA:  Postgrad Med J     Country:  England    
Other Details:
Languages:  eng     Pagination:  594-7     Citation Subset:  IM    
Department of Cardiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology (HUST), Wuhan, Hubei-430030, China.
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MeSH Terms
Angina, Unstable / blood,  drug therapy*
Anti-Inflammatory Agents / therapeutic use*
Cardiovascular Agents / therapeutic use*
Case-Control Studies
Diltiazem / therapeutic use*
Interleukin-10 / blood*
Middle Aged
Reg. No./Substance:
0/Anti-Inflammatory Agents; 0/Cardiovascular Agents; 130068-27-8/Interleukin-10; 42399-41-7/Diltiazem

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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