Document Detail


Anti-inflammatory Endiandric Acid Analogues from the Roots of Beilschmiedia tsangii.
MedLine Citation:
PMID:  21846089     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Bioassay-guided fractionation of roots of Beilschmiedia tsangii led to the isolation of six new endiandric acid analogues: tsangibeilin A (1), tsangibeilin B (2), endiandramide A (3), endiandric acid K (4), endiandric acid L (5), and endiandramide B (6). Also isolated were two new lignans, beilschminol A (7) and tsangin C (8), and six known compounds. The structures of 1-8 were determined by spectroscopic techniques. Compounds 3 and 6 exhibited potent iNOS inhibitory activity, with IC(50) values of 9.59 and 16.40 μM, respectively.
Authors:
Yun-Ting Huang; Hsun-Shuo Chang; Guei-Jane Wang; Ming-Jen Cheng; Chu-Huang Chen; Yi-Jen Yang; Ih-Sheng Chen
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-8-16
Journal Detail:
Title:  Journal of natural products     Volume:  -     ISSN:  1520-6025     ISO Abbreviation:  -     Publication Date:  2011 Aug 
Date Detail:
Created Date:  2011-8-17     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7906882     Medline TA:  J Nat Prod     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Graduate Institute of Natural Products, College of Pharmacy, Kaohsiung Medical University , Kaohsiung, Taiwan 807, Republic of China.
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