| Anti-inflammatory Endiandric Acid Analogues from the Roots of Beilschmiedia tsangii. | |
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MedLine Citation:
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PMID: 21846089 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Bioassay-guided fractionation of roots of Beilschmiedia tsangii led to the isolation of six new endiandric acid analogues: tsangibeilin A (1), tsangibeilin B (2), endiandramide A (3), endiandric acid K (4), endiandric acid L (5), and endiandramide B (6). Also isolated were two new lignans, beilschminol A (7) and tsangin C (8), and six known compounds. The structures of 1-8 were determined by spectroscopic techniques. Compounds 3 and 6 exhibited potent iNOS inhibitory activity, with IC(50) values of 9.59 and 16.40 μM, respectively. |
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Authors:
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Yun-Ting Huang; Hsun-Shuo Chang; Guei-Jane Wang; Ming-Jen Cheng; Chu-Huang Chen; Yi-Jen Yang; Ih-Sheng Chen |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-8-16 |
Journal Detail:
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Title: Journal of natural products Volume: - ISSN: 1520-6025 ISO Abbreviation: - Publication Date: 2011 Aug |
Date Detail:
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Created Date: 2011-8-17 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7906882 Medline TA: J Nat Prod Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Graduate Institute of Natural Products, College of Pharmacy, Kaohsiung Medical University , Kaohsiung, Taiwan 807, Republic of China. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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