Document Detail

Anti-inflammatory and Anti-Bacterial Properties of Tetramethylhexadecenyl Succinoyl Cysteine (TSC): A Skin Protecting Cosmetic Functional Ingredient.
MedLine Citation:
PMID:  25256809     Owner:  NLM     Status:  Publisher    
BACKGROUND: The skin is the first line of defense against exposure to microbial, physical, environmental and chemical insults. In mobilizing a protective response, several different cell types located in our skin release and respond to pro-inflammatory cytokines ensuring skin homeostasis and health. However, chronic activation of this response, eventually causes damage resulting in premature aging. Diosodium Tetramethylhexadecenyl Succinoyl Cysteine (TSC or SIG1273), an isoprenylcysteine (IPC) small molecule down modulates these inflammatory signaling pathways in various cell types (keratinocytes, peripheral blood mononuclear cells (PBMCs) and endothelial cells) and possesses anti-bacterial properties. Thus, TSC represents a novel cosmetic functional ingredient that provides a broad spectrum of benefits for the skin.
OBJECTIVE: To assess the anti-inflammatory properties of TSC in several cutaneous cell types and further investigate its antimicrobial activity.
METHODS: Cultured Normal human epidermal keratinocytes (NHEKs), were exposed to chemical irritant phorbol 12-myrisate 13-acetate (TPA) or Ultraviolet-B light (UVB) to induce pro-inflammatory cytokine (IL-6, IL-8 and TNF-α) production. T-cell receptor (TCR) activation of PBMCs and nickel (Ni(2+) ) treatments of human dermal microvascular endothelial cells (HDMECs) were performed resulting in IL-4, IL-6, IL-8 and IL-17 production. Streptococcus pyogenes were cultured to determine minimal inhibitory concentration (MIC) values.
RESULTS: In vitro studies demonstrate TSC blocks TPA and UVB-induced cytokine production in cultured keratinocytes. Similarly, TSC inhibits overproduction of IL-4 and IL-17 in T-cell Receptor (TCR)-activated PBMCs as well as nickel induction of IL-6 and IL-8 in HDMECs. Lastly, TSC demonstrated antimicrobial properties, inhibiting cell growth of S. pyogenes.
CONCLUSIONS: TSC represents a novel cosmetic functional ingredient that provides a dual modulating benefit of skin protection to individuals by reducing inflammation in keratinocytes, endothelial and mononuclear cell types and S. pyogenes counts. This article is protected by copyright. All rights reserved.
José R Fernandéz; Karl Rouzard; Michael Voronkov; Kristen L Huber; Jeffry B Stock; Maxwell Stock; Joel S Gordon; Eduardo Pérez
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-9-25
Journal Detail:
Title:  International journal of cosmetic science     Volume:  -     ISSN:  1468-2494     ISO Abbreviation:  Int J Cosmet Sci     Publication Date:  2014 Sep 
Date Detail:
Created Date:  2014-9-26     Completed Date:  -     Revised Date:  2014-9-27    
Medline Journal Info:
Nlm Unique ID:  8007161     Medline TA:  Int J Cosmet Sci     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
This article is protected by copyright. All rights reserved.
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