Document Detail


Anti-hyperglycemic Potential of Natural Products.
MedLine Citation:
PMID:  16515474     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In order to evaluate the anti-hyperglycemic effect of natural compounds via the inhibition of alpha-glucosidase (AGH), the potential inhibitory effect of anthocyanins, caffeic acid analogs, and caffeoylquinic acid analogs have been reviewed. A new AGH assay system to mimic the membrane-bound AGH at the small intestine was proposed and evaluated.
Authors:
T Matsui; I A Ogunwande; K J M Abesundara; K Matsumoto
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Mini reviews in medicinal chemistry     Volume:  6     ISSN:  1389-5575     ISO Abbreviation:  Mini Rev Med Chem     Publication Date:  2006 Mar 
Date Detail:
Created Date:  2006-03-06     Completed Date:  2006-05-25     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101094212     Medline TA:  Mini Rev Med Chem     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  349-56     Citation Subset:  IM    
Affiliation:
Division of Food Biotechnology, Department of Bioscience and Biotechnology, Faculty of Agriculture, Graduate School of Kyushu University, 6-10-1 Hakozaki, Higashi-ku, Fukuoka 812-8581, Japan. tmatsui@agr.kyushu-u.ac.jp
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MeSH Terms
Descriptor/Qualifier:
Animals
Anthocyanins / pharmacology,  therapeutic use*
Caffeic Acids / pharmacology,  therapeutic use
Cell Membrane / metabolism
Enzyme Inhibitors / pharmacology,  therapeutic use
Humans
Hyperglycemia / drug therapy*
Hypoglycemic Agents / pharmacology,  therapeutic use*
Intestine, Small / drug effects*,  metabolism
Plant Extracts / chemistry,  pharmacology*
Quinic Acid / analogs & derivatives,  pharmacology,  therapeutic use
alpha-Glucosidases / antagonists & inhibitors,  metabolism
Chemical
Reg. No./Substance:
0/Anthocyanins; 0/Caffeic Acids; 0/Enzyme Inhibitors; 0/Hypoglycemic Agents; 0/Plant Extracts; 0/caffeoylquinic acid; 77-95-2/Quinic Acid; EC 3.2.1.20/alpha-Glucosidases

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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