Document Detail


Anti-Müllerian hormone (AMH) in female reproduction: is measurement of circulating AMH a useful tool?
MedLine Citation:
PMID:  16712660     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Anti-Müllerian hormone (AMH) is a dimeric glycoprotein, a member of the transforming growth factor (TGF) superfamily. It is produced exclusively in the gonads and is involved in the regulation of follicular growth and development. In the ovary AMH is produced by the granulosa cells of early developing follicles and seems to be able to inhibit the initiation of primordial follicle growth and FSH-induced follicle growth. As AMH is largely expressed throughout folliculogenesis, from the primary follicular stage towards the antral stage, serum levels of AMH may represent both the quantity and quality of the ovarian follicle pool. Compared to other ovarian tests, AMH seems to be the best marker reflecting the decline of reproductive age. AMH measurement could be useful in the prediction of the menopausal transition. It could also be used to predict poor ovarian response and possibly the prognosis of in vitro fertilization (IVF) cycles. AMH has been shown to be a good surrogate marker for polycystic ovary syndrome (PCOS). Finally, its use as a marker for granulosa cell tumours has been proposed. A clearer understanding of its role in ovarian physiology may help clinicians to find a role for AMH measurement in the field of reproductive medicine.
Authors:
A La Marca; A Volpe
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Clinical endocrinology     Volume:  64     ISSN:  0300-0664     ISO Abbreviation:  Clin. Endocrinol. (Oxf)     Publication Date:  2006 Jun 
Date Detail:
Created Date:  2006-05-22     Completed Date:  2006-09-15     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0346653     Medline TA:  Clin Endocrinol (Oxf)     Country:  England    
Other Details:
Languages:  eng     Pagination:  603-10     Citation Subset:  IM    
Affiliation:
Mother-Infant Department, Institute of Obstetrics and Gynaecology, University of Modena and Reggio Emilia, Modena, Italy. antlamarca@libero.it
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MeSH Terms
Descriptor/Qualifier:
Adult
Anti-Mullerian Hormone
Biological Markers / blood
Female
Fertilization in Vitro / methods
Follicle Stimulating Hormone / blood
Follicular Phase
Glycoproteins / blood*
Granulosa Cell Tumor / diagnosis
Humans
Menopause / blood
Middle Aged
Ovarian Diseases / blood*
Ovarian Follicle / metabolism*
Ovarian Neoplasms / diagnosis
Testicular Hormones / blood*
Chemical
Reg. No./Substance:
0/Biological Markers; 0/Glycoproteins; 0/Testicular Hormones; 80497-65-0/Anti-Mullerian Hormone; 9002-68-0/Follicle Stimulating Hormone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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