| Anti-hepatitis B virus activity of chlorogenic acid, quinic acid and caffeic acid in vivo and in vitro. | |
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MedLine Citation:
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PMID: 19463857 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Chlorogenic acid and its related compounds are abundant plant polyphenols that have a diverse antiviral activity. In this study, HepG2.2.15 cells and duck hepatitis B virus infection model were used as in vitro and in vivo models to evaluate their anti-HBV activity. In the cell model, all the three compounds inhibited HBV-DNA replication as well as HBsAg production. Chlorogenic acid and caffeic acid also reduced serum DHBV level in DHBV-infected duckling model. Moreover, the anti-HBV activity of crude extracts of coffee beans, which have a high content of chlorogenic acid, was studied. Both the extracts of regular coffee and that of decaffeinated coffee showed inhibitory effect on HBV replication. |
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Authors:
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Gui-Feng Wang; Li-Ping Shi; Yu-Dan Ren; Qun-Fang Liu; Hou-Fu Liu; Ru-Jun Zhang; Zhuang Li; Feng-Hua Zhu; Pei-Lan He; Wei Tang; Pei-Zhen Tao; Chuan Li; Wei-Min Zhao; Jian-Ping Zuo |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2009-05-20 |
Journal Detail:
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Title: Antiviral research Volume: 83 ISSN: 1872-9096 ISO Abbreviation: Antiviral Res. Publication Date: 2009 Aug |
Date Detail:
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Created Date: 2009-06-24 Completed Date: 2009-08-03 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8109699 Medline TA: Antiviral Res Country: Netherlands |
Other Details:
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Languages: eng Pagination: 186-90 Citation Subset: IM |
Affiliation:
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Laboratory of Immunopharmacology, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, People's Republic of China. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antiviral Agents / pharmacology, therapeutic use* Caffeic Acids / pharmacology*, therapeutic use Cell Line Chlorogenic Acid / pharmacology, therapeutic use* Ducks Hepadnaviridae Infections / drug therapy* Hepatitis B Virus, Duck / drug effects* Hepatitis, Viral, Animal / drug therapy* Hepatocytes / virology Humans Inhibitory Concentration 50 Quinic Acid / pharmacology, therapeutic use* Serum / virology Virus Replication / drug effects |
| Chemical | |
Reg. No./Substance:
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0/Antiviral Agents; 0/Caffeic Acids; 327-97-9/Chlorogenic Acid; 331-39-5/caffeic acid; 77-95-2/Quinic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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