| Anti-glucocorticoid effects of progesterone in vivo on rat adipose tissue metabolism. | |
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MedLine Citation:
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PMID: 12906939 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Steroid hormones seem to be important for adipose tissue metabolism and accumulation. As progesterone has been suggested to modulate the glucocorticoid effects, the interactions between glucocortioid and progesterone on adipose tissue metabolism were investigated.Forty-eight male Wistar rats were adrenectomized and divided into four groups; controls (treated with vehicle only), dexamethasone treated (10 micro g per rat), progesterone treated (5mg per rat) and the last group received both dexamethasone and progesterone. The dexamethasone-treated group had a significant loss of body weight and smaller intra-abdominal fat depots compared to the control group in addition, dexamethasone increased LPL-activity and increased catecholamine stimulated lipolysis. When progesterone was given concomitantly the dexamethasone effects on adipose tissue mass, LPL-activity and lipolysis were blocked. When given alone progesterone had no influence on body weight, amount of adipose tissue, lipolysis or LPL-activity. These data indicate that progesterone acts as an anti-glucocorticoid in adipose tissue in vivo, thus attenuating the glucocorticoid effect on adipose tissue metabolism. |
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Authors:
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Steen B Pedersen; Kurt Kristensen; Bjørn Richelsen |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Steroids Volume: 68 ISSN: 0039-128X ISO Abbreviation: Steroids Publication Date: 2003 Aug |
Date Detail:
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Created Date: 2003-08-08 Completed Date: 2004-05-19 Revised Date: 2009-11-03 |
Medline Journal Info:
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Nlm Unique ID: 0404536 Medline TA: Steroids Country: United States |
Other Details:
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Languages: eng Pagination: 543-50 Citation Subset: IM |
Affiliation:
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Department of Endocrinology and Metabolism, Aarhus Amtssygehus, Aarhus University Hospital, DK-8000 Aarhus C., Denmark. amtssp@aau.dk |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adipose Tissue
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drug effects*,
metabolism* Animals Body Weight Catecholamines / pharmacology Dexamethasone / antagonists & inhibitors, pharmacology Glucocorticoids / antagonists & inhibitors*, pharmacology Lipoprotein Lipase / genetics, metabolism Male Progesterone / pharmacology* RNA, Messenger / analysis, drug effects Rats Rats, Wistar |
| Chemical | |
Reg. No./Substance:
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0/Catecholamines; 0/Glucocorticoids; 0/RNA, Messenger; 50-02-2/Dexamethasone; 57-83-0/Progesterone; EC 3.1.1.34/Lipoprotein Lipase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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