Document Detail

Anti-gamete antibodies block transmission of human vivax malaria to mosquitoes.
MedLine Citation:
PMID:  3523397     Owner:  NLM     Status:  MEDLINE    
Antibodies were raised in rabbits by immunizing against fresh unfixed or cryopreserved female gametes of the human malaria pathogen Plasmodium vivax. The antibodies were shown to react with the surface of gametes by the indirect immunofluorescent test. When parasite isolates from P. vivax infected individuals were fed through a membrane to Anopheles tessellatus mosquitoes in the presence of immune rabbit sera, they completely blocked the infectivity of the parasite isolates to the vector. Immunoglobulins separated from these sera also blocked infectivity to the same extent as did the immune sera indicating that antibodies were responsible for the transmission blocking effect of the sera. This study indicated that P. vivax like other malaria parasites is highly susceptible to anti gamete transmission blocking immunity.
Y D Munesinghe; K N Mendis; R Carter
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Parasite immunology     Volume:  8     ISSN:  0141-9838     ISO Abbreviation:  Parasite Immunol.     Publication Date:  1986 May 
Date Detail:
Created Date:  1986-07-25     Completed Date:  1986-07-25     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7910948     Medline TA:  Parasite Immunol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  231-8     Citation Subset:  IM    
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MeSH Terms
Anopheles / parasitology
Antigen-Antibody Reactions
Malaria / immunology,  transmission*
Ovum / immunology
Plasmodium vivax / immunology*

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