Document Detail

Anti-free radical mechanisms in captopril protection against reperfusion injury in isolated rat hearts.
MedLine Citation:
PMID:  9191504     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: Captopril, an angiotensin-converting enzyme (ACE) inhibitor, is known to modulate ischemia-reperfusion injury in the isolated hearts. This study was designed to examine the involvement of anti-free radical mechanisms in this protection. METHODS: Isolated perfused rat hearts were subjected to 60 mins of global ischemia and 30 mins of reperfusion with or without captopril (100 mumol/L). Myocardial resting tension and contractile force were recorded. At the end of reperfusion, hearts were analyzed for the activities of antioxidant enzymes, superoxide dismutase, glutathione peroxidase and catalase, as well as for the extent of lipid peroxidation. Another potent ACE inhibitor, enalapril (100 mumol/L) was used for comparison. RESULTS: Captopril significantly improved the recovery of contractile function as well as attenuated the rise in resting tension in the ischemic-reperfused hearts as compared to the control. Captopril-exposed ischemic-reperfused hearts showed an increase in the activity of superoxide dismutase with no change in glutathione peroxidase and catalase enzyme activities. Lipid peroxidation at the end of reperfusion was significantly attenuated in the captopril-exposed hearts compared to the control. Enalapril had no protective effect against ischemia-reperfusion induced contractile failure or rise in resting force. CONCLUSIONS: These results suggest that cardioprotection by captopril, against ischemia-reperfusion injury, may involve an anti-free radical mechanism independent of its ACE inhibition property.
B Anderson; N Khaper; A K Dhalla; P K Singal
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Publication Detail:
Type:  In Vitro; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Canadian journal of cardiology     Volume:  12     ISSN:  0828-282X     ISO Abbreviation:  Can J Cardiol     Publication Date:  1996 Oct 
Date Detail:
Created Date:  1997-07-07     Completed Date:  1997-07-07     Revised Date:  2008-04-09    
Medline Journal Info:
Nlm Unique ID:  8510280     Medline TA:  Can J Cardiol     Country:  CANADA    
Other Details:
Languages:  eng     Pagination:  1099-104     Citation Subset:  IM    
Institute of Cardiovascular Sciences, St Boniface General Hospital Research Centre, Winnipeg, Manitoba.
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MeSH Terms
Angiotensin-Converting Enzyme Inhibitors / pharmacology*,  therapeutic use
Captopril / pharmacology*,  therapeutic use
Catalase / metabolism
Enalapril / pharmacology
Free Radicals
Glutathione Peroxidase / metabolism
Myocardial Contraction / drug effects
Myocardial Reperfusion Injury / metabolism,  prevention & control*
Rats, Sprague-Dawley
Superoxide Dismutase / metabolism
Reg. No./Substance:
0/Angiotensin-Converting Enzyme Inhibitors; 0/Free Radicals; 62571-86-2/Captopril; 75847-73-3/Enalapril; EC; EC Peroxidase; EC Dismutase

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