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Anti-fibrillin-1 autoantibodies in normal pregnancy and recurrent pregnancy loss.
MedLine Citation:
PMID:  20850568     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
PROBLEM: The aim of this study was to investigate anti-fibrillin-1 autoantibody in patients with a history of recurrent pregnancy loss (RPL) and during normal pregnancy.
METHOD OF STUDY: Anti-fibrillin-1 IgG and IgM antibodies were measured by a home made ELISA in serum samples of 48 medically and obstetrically normal pregnant women, classified to three trimester groups, 15 female patients with RPL and 26 healthy non-pregnant women classified to two control subgroups: (a) women who had already had at least one previous successful pregnancy and (b) women who had never been pregnant. Differences in anti-fibrillin-1 autoantibodies between the groups were analyzed for statistical significance (P<0.05) with one-way analysis of variance (ANOVA) and multiple comparison test - Post Hoc test, Least Significant Difference method.
RESULTS: Anti-fibrillin-1 IgM autoantibodies were significantly decreased in the second and third trimester pregnant women compared to the nulligravida controls. RPL patients had significantly increased anti-fibrillin-1 IgM antibody compared to control group (a).
CONCLUSION: Fibrillin-1 degradation seems to be decreased during the second and third trimester of normal pregnancy. Increased anti-fibrillin-1 IgM antibodies in RPL patients may be a secondary phenomenon of increased fibrillin-1 degradation and contribute to the pathogenesis of pregnancy losses.
Authors:
Milena Atanasova Atanasova; Emiliana Ilieva Konova; Tania Ace Aleksovska; Katia Nikolova Todorova; Miglena Nikolaeva Georgieva; Tzvetan Hristoforov Lukanov
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Publication Detail:
Type:  Journal Article     Date:  2010-09-17
Journal Detail:
Title:  Autoimmunity reviews     Volume:  10     ISSN:  1873-0183     ISO Abbreviation:  Autoimmun Rev     Publication Date:  2011 Jan 
Date Detail:
Created Date:  2011-01-24     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101128967     Medline TA:  Autoimmun Rev     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  131-6     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 Elsevier B.V. All rights reserved.
Affiliation:
Department of Biology, Medical University of Pleven, 1, Kliment Ohridski Str., Pleven, 5800, Bulgaria.
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