| Anti-fibrillin-1 autoantibodies in normal pregnancy and recurrent pregnancy loss. | |
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MedLine Citation:
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PMID: 20850568 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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PROBLEM: The aim of this study was to investigate anti-fibrillin-1 autoantibody in patients with a history of recurrent pregnancy loss (RPL) and during normal pregnancy. METHOD OF STUDY: Anti-fibrillin-1 IgG and IgM antibodies were measured by a home made ELISA in serum samples of 48 medically and obstetrically normal pregnant women, classified to three trimester groups, 15 female patients with RPL and 26 healthy non-pregnant women classified to two control subgroups: (a) women who had already had at least one previous successful pregnancy and (b) women who had never been pregnant. Differences in anti-fibrillin-1 autoantibodies between the groups were analyzed for statistical significance (P<0.05) with one-way analysis of variance (ANOVA) and multiple comparison test - Post Hoc test, Least Significant Difference method. RESULTS: Anti-fibrillin-1 IgM autoantibodies were significantly decreased in the second and third trimester pregnant women compared to the nulligravida controls. RPL patients had significantly increased anti-fibrillin-1 IgM antibody compared to control group (a). CONCLUSION: Fibrillin-1 degradation seems to be decreased during the second and third trimester of normal pregnancy. Increased anti-fibrillin-1 IgM antibodies in RPL patients may be a secondary phenomenon of increased fibrillin-1 degradation and contribute to the pathogenesis of pregnancy losses. |
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Authors:
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Milena Atanasova Atanasova; Emiliana Ilieva Konova; Tania Ace Aleksovska; Katia Nikolova Todorova; Miglena Nikolaeva Georgieva; Tzvetan Hristoforov Lukanov |
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Publication Detail:
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Type: Journal Article Date: 2010-09-17 |
Journal Detail:
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Title: Autoimmunity reviews Volume: 10 ISSN: 1873-0183 ISO Abbreviation: Autoimmun Rev Publication Date: 2011 Jan |
Date Detail:
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Created Date: 2011-01-24 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101128967 Medline TA: Autoimmun Rev Country: Netherlands |
Other Details:
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Languages: eng Pagination: 131-6 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 Elsevier B.V. All rights reserved. |
Affiliation:
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Department of Biology, Medical University of Pleven, 1, Kliment Ohridski Str., Pleven, 5800, Bulgaria. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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