Document Detail

Anti-endothelial antibodies and neuropsychiatric systemic lupus erythematosus.
MedLine Citation:
PMID:  16855139     Owner:  NLM     Status:  MEDLINE    
The pathogenesis of neuropsychiatric systemic lupus erythematosus (NPSLE) has been attributed to autoantibody-mediated neural dysfunction, vasculopathy, and coagulopathy. Several autoantibodies specificities have been reported in serum and cerebrospinal fluid of NPSLE patients (i.e., antineuronal, antiribosomal P proteins, antiglial fibrillary acidic proteins, antiphospholipid, and anti-endothelial antibodies). We have recently demonstrated an association between serum anti-endothelial antibodies and psychosis or depression in patients with SLE. Subsequently, by screening a cDNA library from human umbilical artery endothelial cells with serum from a SLE patient with psychosis, one positive strongly reactive clone was identified encoding the C-terminal region (C-ter) of Nedd5, an intracytoplasmatic protein of the septin family. Anti-Nedd5 antibodies have been found significantly associated with psychiatric manifestations in SLE patients, strengthening the view of a possible implication of autoantibodies in the development of psychiatric disorders.
Guido Valesini; Cristiano Alessandri; Domenico Celestino; Fabrizio Conti
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Annals of the New York Academy of Sciences     Volume:  1069     ISSN:  0077-8923     ISO Abbreviation:  Ann. N. Y. Acad. Sci.     Publication Date:  2006 Jun 
Date Detail:
Created Date:  2006-07-20     Completed Date:  2006-08-23     Revised Date:  2010-10-27    
Medline Journal Info:
Nlm Unique ID:  7506858     Medline TA:  Ann N Y Acad Sci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  118-28     Citation Subset:  IM    
Dipartimento di Clinica e Terapia Medica Applicata, Cattedra e Divisione di Reumatologia, Università La Sapienza, V.le del Policlinico 155, 00161 Rome, Italy.
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MeSH Terms
Antibodies / immunology*
Endothelium / immunology*
Lupus Vasculitis, Central Nervous System / immunology*
Phosphoric Monoester Hydrolases / immunology
Reg. No./Substance:
0/Antibodies; EC 3.1.3.-/Phosphoric Monoester Hydrolases

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