| Anti-emetic efficacy of prophylactic granisetron, droperidol and metoclopramide in the prevention of nausea and vomiting after laparoscopic cholecystectomy: a randomized, double-blind, placebo-controlled trial. | |
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MedLine Citation:
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PMID: 9587723 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This study evaluates the prophylactic anti-emetic efficacy of granisetron, droperidol and metoclopramide, for the prevention of post-operative nausea and vomiting in female patients undergoing elective laparoscopic cholecystectomy. The patients were randomly assigned to one of four groups (n = 30 for each group): granisetron 3 mg, droperidol 1.25 mg, metoclopramide 10 mg and placebo (saline). These medications were given immediately before the induction of anaesthesia. During the first 24 h after anaesthesia, the incidence of post-operative nausea and vomiting was 13, 30, 33 and 37% after administration of granisetron, droperidol, metoclopramide and placebo, respectively (P < 0.05, overall Fisher's exact probability test). No clinically important adverse effects were observed in either group. Our results suggest that granisetron is a better anti-emetic than droperidol or metoclopramide for the prevention of post-operative nausea and vomiting after laparoscopic cholecystectomy when compared with a placebo. |
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Authors:
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Y Fujii; Y Saitoh; H Tanaka; H Toyooka |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: European journal of anaesthesiology Volume: 15 ISSN: 0265-0215 ISO Abbreviation: Eur J Anaesthesiol Publication Date: 1998 Mar |
Date Detail:
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Created Date: 1998-07-13 Completed Date: 1998-07-13 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 8411711 Medline TA: Eur J Anaesthesiol Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 166-71 Citation Subset: IM |
Affiliation:
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Department of Anaesthesiology, University of Tsukuba Institute of Clinical Medicine, Ibaraki, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Antiemetics / therapeutic use* Cholecystectomy, Laparoscopic* Double-Blind Method Droperidol / therapeutic use* Female Granisetron / therapeutic use* Humans Metoclopramide / therapeutic use* Middle Aged Nausea / prevention & control* Vomiting / prevention & control* |
| Chemical | |
Reg. No./Substance:
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0/Antiemetics; 109889-09-0/Granisetron; 364-62-5/Metoclopramide; 548-73-2/Droperidol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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