Document Detail

Anti-emetic efficacy of prophylactic granisetron, droperidol and metoclopramide in the prevention of nausea and vomiting after laparoscopic cholecystectomy: a randomized, double-blind, placebo-controlled trial.
MedLine Citation:
PMID:  9587723     Owner:  NLM     Status:  MEDLINE    
This study evaluates the prophylactic anti-emetic efficacy of granisetron, droperidol and metoclopramide, for the prevention of post-operative nausea and vomiting in female patients undergoing elective laparoscopic cholecystectomy. The patients were randomly assigned to one of four groups (n = 30 for each group): granisetron 3 mg, droperidol 1.25 mg, metoclopramide 10 mg and placebo (saline). These medications were given immediately before the induction of anaesthesia. During the first 24 h after anaesthesia, the incidence of post-operative nausea and vomiting was 13, 30, 33 and 37% after administration of granisetron, droperidol, metoclopramide and placebo, respectively (P < 0.05, overall Fisher's exact probability test). No clinically important adverse effects were observed in either group. Our results suggest that granisetron is a better anti-emetic than droperidol or metoclopramide for the prevention of post-operative nausea and vomiting after laparoscopic cholecystectomy when compared with a placebo.
Y Fujii; Y Saitoh; H Tanaka; H Toyooka
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial; Retracted Publication    
Journal Detail:
Title:  European journal of anaesthesiology     Volume:  15     ISSN:  0265-0215     ISO Abbreviation:  Eur J Anaesthesiol     Publication Date:  1998 Mar 
Date Detail:
Created Date:  1998-07-13     Completed Date:  1998-07-13     Revised Date:  2014-04-03    
Medline Journal Info:
Nlm Unique ID:  8411711     Medline TA:  Eur J Anaesthesiol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  166-71     Citation Subset:  IM    
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MeSH Terms
Antiemetics / therapeutic use*
Cholecystectomy, Laparoscopic*
Double-Blind Method
Droperidol / therapeutic use*
Granisetron / therapeutic use*
Metoclopramide / therapeutic use*
Middle Aged
Nausea / prevention & control*
Vomiting / prevention & control*
Reg. No./Substance:
0/Antiemetics; L4YEB44I46/Metoclopramide; O9U0F09D5X/Droperidol; WZG3J2MCOL/Granisetron
Retraction In:
Eur J Anaesthesiol. 2013 May;30(5):262   [PMID:  23571436 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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