Document Detail

Anti-diabetic activity of chromium picolinate and biotin in rats with type 2 diabetes induced by high-fat diet and streptozotocin.
MedLine Citation:
PMID:  23211098     Owner:  NLM     Status:  Publisher    
The objective of the present study was to evaluate anti-diabetic effects of chromium picolinate (CrPic) and biotin supplementations in type 2 diabetic rats. The type 2 diabetic rat model was induced by high-fat diet (HFD) and low-dose streptozotocin. The rats were divided into five groups as follows: (1) non-diabetic rats fed a regular diet; (2) diabetic rats fed a HFD; (3) diabetic rats fed a HFD and supplemented with CrPic (80 μg/kg body weight (BW) per d); (4) diabetic rats fed a HFD and supplemented with biotin (300 μg/kg BW per d); (5) diabetic rats fed a HFD and supplemented with both CrPic and biotin. Circulating glucose, cortisol, total cholesterol, TAG, NEFA and malondialdehyde concentrations decreased (P < 0·05), but serum insulin concentrations increased (P < 0·05) in diabetic rats treated with biotin and CrPic, particularly with a combination of the supplements. Feeding a HFD to diabetic rats decreased PPAR-γ expression in adipose tissue and phosphorylated insulin receptor substrate 1 (p-IRS-1) expression of liver, kidney and muscle tissues, while the supplements increased (P < 0·001) PPAR-γ and p-IRS-1 expressions in relevant tissues. Expression of NF-κB in the liver and kidney was greater in diabetic rats fed a HFD, as compared with rats fed a regular diet (P < 0·01). The supplements decreased the expression of NF-κB in diabetic rats (P < 0·05). Results of the present study revealed that supplementing CrPic and biotin alone or in a combination exerts anti-diabetic activities, probably through modulation of PPAR-γ, IRS-1 and NF-κB proteins.
Kazim Sahin; Mehmet Tuzcu; Cemal Orhan; Nurhan Sahin; Osman Kucuk; Ibrahim H Ozercan; Vijaya Juturu; James R Komorowski
Related Documents :
23899518 - Placenta mesenchymal stem cell accelerates wound healing by enhancing angiogenesis in d...
23636998 - Duodenal-jejunal bypass improves glucose metabolism and adipokine expression independen...
17230618 - Short-term application of low-dose growth hormone in surgical patients: effects on nitr...
19246588 - Effects of prandial versus fasting glycemia on cardiovascular outcomes in type 2 diabet...
23093658 - Vegfa protects the glomerular microvasculature in diabetes.
24527778 - Peroxisome proliferator-activated receptor-β activation restores the high glucose-indu...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-12-5
Journal Detail:
Title:  The British journal of nutrition     Volume:  -     ISSN:  1475-2662     ISO Abbreviation:  Br. J. Nutr.     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-12-5     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0372547     Medline TA:  Br J Nutr     Country:  -    
Other Details:
Languages:  ENG     Pagination:  1-9     Citation Subset:  -    
Department of Animal Nutrition, Faculty of Veterinary Science, Firat University, Elazig 23119, Turkey.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  It takes more to forgive: The role of executive control.
Next Document:  Identification of New Potent GPR119 Agonists by Combining Virtual Screening and Combinatorial Chemis...