Document Detail

Anti-cardiolipin antibodies and overall survival in a large cohort: preliminary report.
MedLine Citation:
PMID:  16574758     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Anti-cardiolipin antibodies have been associated with both arterial and venous thrombosis, but their overall impact on all-cause or vascular mortality is unknown. In this study, we evaluated the influence of anti-cardiolipin antibodies on all-cause and vascular mortality. METHODS: All individuals who fulfilled the inclusion criteria (completeness of data, no admission from an intensive care unit, unique identification with name and date of birth) and whose anti-cardiolipin antibodies were measured between October 2002 and February 2004 were included in this study (n = 4756; 64% female; median age, 46 years). Death/survival and cause of death were obtained from the Austrian Death Registry. The median observation period was 1.5 years, and the study comprised 7189 person-years. RESULTS: During the study period, 184 patients (3.9%) died. There were no associations between either anti-cardiolipin IgM or IgG antibodies and both vascular death and noncancer mortality as outcome variables in a Cox regression analysis adjusted for age and sex. In contrast, the risk of cancer-related mortality was increased 2.6-fold. CONCLUSIONS: Anti-cardiolipin antibodies are associated with cancer mortality, likely as an epiphenomenon of malignancy, but they are not predictive of vascular mortality or noncancer mortality. Hence, although a clear association between anti-cardiolipin antibodies and (mostly nonfatal) vascular events has been described in the literature, our data indicate that this finding is not necessarily associated with an increase in vascular mortality.
Georg Endler; Claudia Marsik; Bernd Jilma; Thomas Schickbauer; Rainer Vormittag; Oswald Wagner; Christine Mannhalter; Helmut Rumpold; Ingrid Pabinger
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Publication Detail:
Type:  Journal Article     Date:  2006-03-30
Journal Detail:
Title:  Clinical chemistry     Volume:  52     ISSN:  0009-9147     ISO Abbreviation:  Clin. Chem.     Publication Date:  2006 Jun 
Date Detail:
Created Date:  2006-05-25     Completed Date:  2006-06-27     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9421549     Medline TA:  Clin Chem     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1040-4     Citation Subset:  IM    
Institute of Medical and Chemical Laboratory Diagnostics, Department of Clinical Pharmacology, Division of Haematology and Immunology, Medical University of Vienna, Vienna, Austria.
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MeSH Terms
Autoantibodies / blood*
Cardiolipins / immunology*
Cohort Studies
Middle Aged
Survival Rate*
Vascular Diseases / immunology,  mortality
Reg. No./Substance:
0/Autoantibodies; 0/Cardiolipins

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