Document Detail


Anti-cardiolipin antibodies and overall survival in a large cohort: preliminary report.
MedLine Citation:
PMID:  16574758     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Anti-cardiolipin antibodies have been associated with both arterial and venous thrombosis, but their overall impact on all-cause or vascular mortality is unknown. In this study, we evaluated the influence of anti-cardiolipin antibodies on all-cause and vascular mortality. METHODS: All individuals who fulfilled the inclusion criteria (completeness of data, no admission from an intensive care unit, unique identification with name and date of birth) and whose anti-cardiolipin antibodies were measured between October 2002 and February 2004 were included in this study (n = 4756; 64% female; median age, 46 years). Death/survival and cause of death were obtained from the Austrian Death Registry. The median observation period was 1.5 years, and the study comprised 7189 person-years. RESULTS: During the study period, 184 patients (3.9%) died. There were no associations between either anti-cardiolipin IgM or IgG antibodies and both vascular death and noncancer mortality as outcome variables in a Cox regression analysis adjusted for age and sex. In contrast, the risk of cancer-related mortality was increased 2.6-fold. CONCLUSIONS: Anti-cardiolipin antibodies are associated with cancer mortality, likely as an epiphenomenon of malignancy, but they are not predictive of vascular mortality or noncancer mortality. Hence, although a clear association between anti-cardiolipin antibodies and (mostly nonfatal) vascular events has been described in the literature, our data indicate that this finding is not necessarily associated with an increase in vascular mortality.
Authors:
Georg Endler; Claudia Marsik; Bernd Jilma; Thomas Schickbauer; Rainer Vormittag; Oswald Wagner; Christine Mannhalter; Helmut Rumpold; Ingrid Pabinger
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Publication Detail:
Type:  Journal Article     Date:  2006-03-30
Journal Detail:
Title:  Clinical chemistry     Volume:  52     ISSN:  0009-9147     ISO Abbreviation:  Clin. Chem.     Publication Date:  2006 Jun 
Date Detail:
Created Date:  2006-05-25     Completed Date:  2006-06-27     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9421549     Medline TA:  Clin Chem     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1040-4     Citation Subset:  IM    
Affiliation:
Institute of Medical and Chemical Laboratory Diagnostics, Department of Clinical Pharmacology, Division of Haematology and Immunology, Medical University of Vienna, Vienna, Austria.
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MeSH Terms
Descriptor/Qualifier:
Adult
Autoantibodies / blood*
Cardiolipins / immunology*
Cohort Studies
Female
Humans
Male
Middle Aged
Mortality*
Risk
Survival Rate*
Vascular Diseases / immunology,  mortality
Chemical
Reg. No./Substance:
0/Autoantibodies; 0/Cardiolipins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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