Document Detail

Anti-cardiolipin antibodies and endothelial function in patients with coronary artery disease.
MedLine Citation:
PMID:  18394439     Owner:  NLM     Status:  MEDLINE    
Endothelial dysfunction is considered an important marker in atherosclerosis, having a prognostic value. Antiphospholipid antibodies are considered prothrombotic and have recently been reported to be associated also with atherosclerosis. This study was conducted to investigate a possible association of endothelial dysfunction with various antiphospholipid autoantibodies in healthy subjects and patients with cardiovascular disease. In a single-center, prospective study, 2 groups were included. The study group included patients with cardiovascular diseases (coronary disease and/or cerebrovascular disease) and healthy subjects without apparent heart disease who were referred to the endothelial function laboratory for the assessment of endothelial function. Flow-mediated dilatation, which indicates endothelial function, and nitroglycerin-mediated vasodilatation, which indicates smooth-muscle function, were measured. The 2 groups were evaluated for autoantibodies, including anticardiolipin (aCL; immunoglobulin G [IgG], immunoglobulin M [IgM], and immunoglobulin A [IgA]), antinuclear antibody, anti-beta2-glycoprotein I (IgG, IgM, and IgA), and oxidized low-density lipoprotein. One hundred seven subjects were included in the study: 45 patients (42%) and 62 healthy controls (58%). Flow-mediated dilatation was significantly lower in patients compared with healthy controls (8.0 +/- 9.5% vs 8.0 +/- 13.5%, p = 0.012). In addition, nitroglycerin-mediated vasodilatation was nonsignificantly lower in patients than in healthy controls (8.0 +/- 13.4% vs 11.0 +/- 16.7%, p = 0.084). The mean levels of anti-beta2-glycoprotein I (IgG, IgM, and IgA), aCL (IgM and IgA), antinuclear antibody, and oxidized low-density lipoprotein were not different between groups. However, the mean level of IgG aCL was significantly higher in patients than in healthy controls. In conclusion, in accordance with previous reports of an association between aCL and atherosclerosis, patients with cardiovascular disease had endothelial dysfunction and elevated levels of aCL.
Ibrahim Marai; Michael Shechter; Pnina Langevitz; Boris Gilburd; Ardon Rubenstein; Eiji Matssura; Yaniv Sherer; Yehuda Shoenfeld
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Publication Detail:
Type:  Journal Article     Date:  2008-02-07
Journal Detail:
Title:  The American journal of cardiology     Volume:  101     ISSN:  0002-9149     ISO Abbreviation:  Am. J. Cardiol.     Publication Date:  2008 Apr 
Date Detail:
Created Date:  2008-04-08     Completed Date:  2008-06-17     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0207277     Medline TA:  Am J Cardiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1094-7     Citation Subset:  AIM; IM    
Heart Institute, Sheba Medical Center, Tel Hashomer, Israel.
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MeSH Terms
Aged, 80 and over
Antibodies / blood*
Brachial Artery / physiology,  ultrasonography
Cardiolipins / immunology*
Case-Control Studies
Coronary Artery Disease / immunology*,  physiopathology*
Endothelium, Vascular / physiopathology*
Immunoglobulin G / immunology
Middle Aged
Prospective Studies
Regional Blood Flow / physiology
Vasodilation / physiology
Reg. No./Substance:
0/Antibodies; 0/Cardiolipins; 0/Immunoglobulin G

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