Document Detail


Anti-cardiolipin and anti-beta 2-glycoprotein I antibodies in celiac disease.
MedLine Citation:
PMID:  21839587     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
AIMS: To determine the frequency of anti-cardiolipin (aCL) and anti-β2-glycoprotein I antibodies (aβ2GPI) in celiac disease (CD) patients. PATIENTS AND METHODS: Sixty-three untreated CD patients and 40 healthy blood donors (HBD) were studied. IgG, IgA and IgM aCL and aβ2GPI were detected by Elisa. RESULTS: The frequency of antiphospholipid antibodies (aPL) (aCL and/or aβ2GPI) was significantly higher in CD patients (12 out of 63) than in HBD (two out of 40) (19% vs 5%, P=0.04). Six CD patients out of 63 (9.5%) and one HBD out of 40 (2.5%) had aCL. Ten CD patients (15.9%) and two HBD (5%) had aβ2GPI. Only aβ2GPI-IgA was significantly more frequent in CD patients than in HBD (14.3% vs 2.5%, P=0.048). In CD patients, aβ2GPI-IgA (nine out of 63) was significantly more frequent (14.3%) than aβ2GPI-IgG (1.6%) and IgM (1.6%) (P=0.008). In CD patients, the frequency of aCL-IgA and IgM was 6.3% (four out of 63) and aCL-IgG were not detected. Simultaneous presence of positive antibodies was found in four CD patients: one patient had four aPL, one had three aPL and two had two aPL. The four patients who had aCL-IgA had also aβ2GPI-IgA and three of them had a titer higher than 50 units. Among nine patients with aβ2GPI-IgA, four had a titer higher than 100 units. The highest titers were found in adults. CONCLUSIONS: aPL and particularly aβ2GPI-IgA are frequent in CD. The significance of these antibodies has to be determined.
Authors:
A Mankaï; A Achour; Y Thabet; W Manoubia; W Sakly; I Ghedira
Related Documents :
17898197 - Linear t2 hyperintensity along the medial margin of the globus pallidus in patients wit...
2685647 - Motor complications associated with chronic levodopa therapy in parkinson's disease.
20176597 - Increased serum insulin-like growth factor 1 in early idiopathic parkinson's disease.
9109747 - Sensory perception in parkinson disease.
17595807 - Role of early serial change in serum carcinoembryonic antigen levels as a predictive ma...
16946987 - Diagnostic contribution of virtual endoscopy in diseases of the upper airways.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-8-10
Journal Detail:
Title:  Pathologie-biologie     Volume:  -     ISSN:  1768-3114     ISO Abbreviation:  -     Publication Date:  2011 Aug 
Date Detail:
Created Date:  2011-8-15     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0265365     Medline TA:  Pathol Biol (Paris)     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2011 Elsevier Masson SAS. All rights reserved.
Affiliation:
Research Unit (03UR/07-02), Faculty of Pharmacy, Monastir, Tunisia.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  A common environmental carcinogen unduly affects carriers of cancer mutations: Carriers of genetic m...
Next Document:  Characteristics of drug users who witness many overdoses: implications for overdose prevention.