Document Detail


Anti-carcinogenic and anti-metastatic properties of indole-3-carbinol in prostate cancer.
MedLine Citation:
PMID:  15583807     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Indole-3-carbinol (I3C), a compound present as glucobracissin in cruciferous vegetables has anticancer activities which is in line with some of the epidemiological evidence that suggests a beneficial effect of consumption of cruciferous vegetables on cancer incidence and progression. The precise target of indole-3-carbinol has not been determined. We examined the effect of I3C on prostate cancer in a well-defined R3327 model using Copenhagen rats and the transplantable cell line, MAT-LyLu. This cell line derived from a tumor in Copenhagen rats is androgen independent and metastasizes to the lung and lymph nodes. Tumors were induced in Copenhagen rats by injecting MAT-LyLu subcutaneously and the animals treated with I3C that was administered either intraperitoneally or intravenously, in order to achieve maximal systemic exposure. This was a departure from the traditional chemopreventive route of indole-3-carbinol where the compound was incorporated in the diet. Our results indicate that I3C inhibited the incidence, growth and metastases of MAT-LyLu cells and both i.p. and i.v. injections of I3C were equally effective. Statistical analysis (Kaplan-Meier curves) clearly indicates a tumor-free and overall survival benefit as a result of treatment with I3C. These studies show for the first time that I3C in an injectible form has anti-prostate cancer activity.
Authors:
V P S Garikapaty; B T Ashok; Y G Chen; A Mittelman; M Iatropoulos; R K Tiwari
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Oncology reports     Volume:  13     ISSN:  1021-335X     ISO Abbreviation:  Oncol. Rep.     Publication Date:  2005 Jan 
Date Detail:
Created Date:  2004-12-07     Completed Date:  2005-04-25     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9422756     Medline TA:  Oncol Rep     Country:  Greece    
Other Details:
Languages:  eng     Pagination:  89-93     Citation Subset:  IM    
Affiliation:
Department of Microbiology and Immunology, New York Medical College, Valhalla, NY 10595, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Anticarcinogenic Agents / therapeutic use*
Disease Models, Animal
Indoles / therapeutic use*
Lung Neoplasms / prevention & control,  secondary
Male
Neoplasm Transplantation
Prostatic Neoplasms / pathology,  prevention & control*
Rats
Rats, Inbred Strains
Tumor Cells, Cultured
Chemical
Reg. No./Substance:
0/Anticarcinogenic Agents; 0/Indoles; 700-06-1/indole-3-carbinol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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