| Anti-carcinogenic and anti-metastatic properties of indole-3-carbinol in prostate cancer. | |
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MedLine Citation:
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PMID: 15583807 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Indole-3-carbinol (I3C), a compound present as glucobracissin in cruciferous vegetables has anticancer activities which is in line with some of the epidemiological evidence that suggests a beneficial effect of consumption of cruciferous vegetables on cancer incidence and progression. The precise target of indole-3-carbinol has not been determined. We examined the effect of I3C on prostate cancer in a well-defined R3327 model using Copenhagen rats and the transplantable cell line, MAT-LyLu. This cell line derived from a tumor in Copenhagen rats is androgen independent and metastasizes to the lung and lymph nodes. Tumors were induced in Copenhagen rats by injecting MAT-LyLu subcutaneously and the animals treated with I3C that was administered either intraperitoneally or intravenously, in order to achieve maximal systemic exposure. This was a departure from the traditional chemopreventive route of indole-3-carbinol where the compound was incorporated in the diet. Our results indicate that I3C inhibited the incidence, growth and metastases of MAT-LyLu cells and both i.p. and i.v. injections of I3C were equally effective. Statistical analysis (Kaplan-Meier curves) clearly indicates a tumor-free and overall survival benefit as a result of treatment with I3C. These studies show for the first time that I3C in an injectible form has anti-prostate cancer activity. |
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Authors:
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V P S Garikapaty; B T Ashok; Y G Chen; A Mittelman; M Iatropoulos; R K Tiwari |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S. |
Journal Detail:
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Title: Oncology reports Volume: 13 ISSN: 1021-335X ISO Abbreviation: Oncol. Rep. Publication Date: 2005 Jan |
Date Detail:
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Created Date: 2004-12-07 Completed Date: 2005-04-25 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9422756 Medline TA: Oncol Rep Country: Greece |
Other Details:
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Languages: eng Pagination: 89-93 Citation Subset: IM |
Affiliation:
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Department of Microbiology and Immunology, New York Medical College, Valhalla, NY 10595, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Anticarcinogenic Agents / therapeutic use* Disease Models, Animal Indoles / therapeutic use* Lung Neoplasms / prevention & control, secondary Male Neoplasm Transplantation Prostatic Neoplasms / pathology, prevention & control* Rats Rats, Inbred Strains Tumor Cells, Cultured |
| Chemical | |
Reg. No./Substance:
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0/Anticarcinogenic Agents; 0/Indoles; 700-06-1/indole-3-carbinol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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