Document Detail


Anti-cancer effects of Phyllanthus urinaria and relevant mechanisms.
MedLine Citation:
PMID:  20979698     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Phyllanthus urinaria (P. urinaria), a widely used herbal medicine, has been reported to possess various biological activities. This report aimed to characterize the whole P. urinaria plant, present the anticancer effects of P. urinaria both in vivo and in vitro, and explore relevant mechanisms. The water extract of P. urinaria not only significantly reduces the cell viability of various cancer cell lines from different origins but also suppresses tumor development in C57BL/6J mice after implantation of Lewis lung carcinoma (LCC) cells. The anticancer activity of P. urinaria extract is mainly due to induced apoptosis of cancer cells as demonstrated by DNA fragmentation and increased caspase-3 activity through both intrinsic and extrinsic pathways. The decrease in viability with P. urinaria treatment might be partially associated with down-regulation of telomerase activation and induction of the apoptotic process. In addition, P. urinaria also exhibits anti-angiogenic activity that is mediated, at least in part, by suppression of matrix metalloproteinase 2 (MMP-2) secretion and inhibition of MMP-2 activity through zinc chelation.
Authors:
Sheng-Teng Huang; Jong-Hwei S Pang; Rong-Chi Yang
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Chang Gung medical journal     Volume:  33     ISSN:  2309-835X     ISO Abbreviation:  Chang Gung Med J     Publication Date:    2010 Sep-Oct
Date Detail:
Created Date:  2010-10-28     Completed Date:  2011-02-22     Revised Date:  2013-10-22    
Medline Journal Info:
Nlm Unique ID:  101088034     Medline TA:  Chang Gung Med J     Country:  China (Republic : 1949- )    
Other Details:
Languages:  eng     Pagination:  477-87     Citation Subset:  IM    
Affiliation:
Department of Chinese Medicine, Chang Gung Memorial Hospital-Kaohsiung Medical Center, Chang Gung University College of Medicine, Kaohsiung, Taiwan. shenteng@cgmh.org.tw
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MeSH Terms
Descriptor/Qualifier:
Angiogenesis Inhibitors / pharmacology
Animals
Antineoplastic Agents, Phytogenic / pharmacology*,  therapeutic use
Apoptosis / drug effects
Chromatography, High Pressure Liquid
Humans
Matrix Metalloproteinase 2 / metabolism
Mice
Mice, Inbred C57BL
Phyllanthus* / chemistry
Phytotherapy*
Plant Extracts / pharmacology*
Telomerase / antagonists & inhibitors
Chemical
Reg. No./Substance:
0/Angiogenesis Inhibitors; 0/Antineoplastic Agents, Phytogenic; 0/Plant Extracts; EC 2.7.7.49/Telomerase; EC 3.4.24.24/Matrix Metalloproteinase 2

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