Document Detail


Anti-breast cancer potential of daidzein in rodents.
MedLine Citation:
PMID:  23227466     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Aims: This study was carried out to explore anti-breast cancer potential of isoflavone daidzein or its related compounds using appropriate animal models and their anti-tumor mechanism.Main methods: Daidzein or its major metabolite equol at a dose molar equivalent to tamoxifen [1.0 mg(2.7 μmol)/kg or 10 mg (27 μmol)/kg/day] was treated orally to rats bearing 7,12-dimethylbenz(a)anthracene(DMBA)-induced mammary tumors or ovariectomized athymic nude mice implanted with human MCF-7 breast cancer xenograft and an estrogen pellet. The growth of tumors was monitored for several weeks after the treatment. The cell-cycle and apoptotic stages in mammary tumors collected from rats were analyzed by flow cytometry. Immunohistochemistry analysis was also used to determine the expression of caspase-3.Key findings: Oral treatment with daidzein or equol at a human equivalent dose suppressed the growth of both DMBA-induced mammary tumors and human MCF-7 breast cancer xenografts in rodents, the inhibitory activity being superior to that of genistein or tamoxifen. Strong apoptosis induced by daidzein or equol contributes to the anti-tumor potential.Significance: Daidzein and its metabolite equol showed the potential of inhibiting the growth of mammary tumors in rodents. Daidzein or equol could be used as a core structure to design new drugs for breast cancer therapy. Our results indicate that consumption of daidzein may protect against breast cancer.
Authors:
Xiaoping Liu; Naomi Suzuki; Y R Santosh Laxmi; Yoshinori Okamoto; Shinya Shibutani
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Life sciences     Volume:  91     ISSN:  1879-0631     ISO Abbreviation:  Life Sci.     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-12-03     Completed Date:  2012-12-10     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0375521     Medline TA:  Life Sci     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  415-9     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Antineoplastic Agents / therapeutic use*
Apoptosis
Female
Growth Inhibitors / therapeutic use*
Isoflavones / therapeutic use*
Mammary Neoplasms, Experimental / drug therapy*,  pathology
Mice
Rats
Chemical
Reg. No./Substance:
0/Antineoplastic Agents; 0/Growth Inhibitors; 0/Isoflavones; 6287WC5J2L/daidzein

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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