| Anti-brain antibodies in adult patients with obsessive-compulsive disorder. | |
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MedLine Citation:
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PMID: 19138800 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: An autoimmune hypothesis has been suggested for a subtype of Obsessive-Compulsive Disorder (OCD) with childhood onset: obsessions, compulsions and/or tics would result from anti-streptococcal antibodies that cross-react with basal ganglia tissue based on molecular mimicry. Consistent with this hypothesis anti-brain antibodies were detected in sera of children with OCD and/or Tourette's syndrome. In the present study, we tested whether adults with OCD have anti-brain antibodies or other antibodies that serve as markers of autoimmunity. METHODS: Seventy-four DSM-IV OCD (YBOCS> or =16) subjects were recruited and compared to 44 controls with a current Major Depressive Episode for neurological symptoms, ALSO titres, anti-tissue and anti-thyroid antibodies. Anti-brain antibodies were tested by immunohistochemistry and Western blotting methods. RESULTS: The proportion of subjects with tic comorbidity or positive ASLO titre (>200 IU/ml) was significantly greater in OCD than in MDE patients (21.6 vs. 2.3% and 16.3 vs. 2.3%, respectively). No other differences in antibody parameters were found. 4/74 OCD patients (5.4%) and none of the controls resulted positive for anti-brain antibodies, with a band around 50-60 kDa at the Western blot analysis. LIMITATIONS: The methodology used to assess anti-brain antibodies. CONCLUSIONS: The majority of adult OCD patients do not seem to have autoimmunity disturbances as compared to a control group. However, a greater percentage of subjects with positive ASLO titres were found among OCD patients. For a small proportion of OCD patients, moreover, autoimmune reactions towards neuronal structures are present although further investigations are needed to demonstrate its etiopathogenetic relevance. |
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Authors:
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Giuseppe Maina; Umberto Albert; Filippo Bogetto; Cristina Borghese; Alberto Cat Berro; Roberto Mutani; Ferdinando Rossi; Maria Claudia Vigliani |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2009-01-12 |
Journal Detail:
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Title: Journal of affective disorders Volume: 116 ISSN: 1573-2517 ISO Abbreviation: J Affect Disord Publication Date: 2009 Aug |
Date Detail:
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Created Date: 2009-06-22 Completed Date: 2009-09-30 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7906073 Medline TA: J Affect Disord Country: Netherlands |
Other Details:
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Languages: eng Pagination: 192-200 Citation Subset: IM |
Affiliation:
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Department of Neuroscience, Mood and Anxiety Disorders Unit, University of Turin, Italy. giuseppemaina@hotmail.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Age of Onset Antibodies, Anti-Idiotypic / immunology* Basal Ganglia / immunology Blotting, Western Brain / immunology*, pathology Depressive Disorder, Major / diagnosis, immunology Female Humans Immunohistochemistry Male Obsessive-Compulsive Disorder / diagnosis, immunology* Thyroid Gland / immunology Tics / immunology Tourette Syndrome / diagnosis, immunology |
| Chemical | |
Reg. No./Substance:
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0/Antibodies, Anti-Idiotypic |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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