| Anti-atherosclerotic activity of triacsin C, an acyl-CoA synthetase inhibitor. | |
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MedLine Citation:
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PMID: 18653998 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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As previously reported, triacsin C, a selective inhibitor of acyl-CoA synthetase, inhibited the synthesis of cholesteryl ester and triacylglycerol in mouse peritoneal macrophages, leading to a reduction of lipid droplets. Therefore, the in vivo efficacy was studied. Low-density lipoprotein receptor-knockout (LDLR-/-) mice were fed a high cholesterol diet (0.15%) for two months to measure the atherogenic areas of the hearts and aortas. When triacsin C was orally administered (10 mg/kg/day), the atherosclerotic areas were significantly reduced by 86% in aorta and 36% in hearts. The results strongly suggested that triacsin C shows anti-atherogenic activity by inhibiting acyl-CoA synthetase activity. |
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Authors:
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Daisuke Matsuda; Ichiji Namatame; Taichi Ohshiro; Shun Ishibashi; Satoshi Omura; Hiroshi Tomoda |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The Journal of antibiotics Volume: 61 ISSN: 0021-8820 ISO Abbreviation: J. Antibiot. Publication Date: 2008 May |
Date Detail:
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Created Date: 2008-07-25 Completed Date: 2008-10-17 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0151115 Medline TA: J Antibiot (Tokyo) Country: Japan |
Other Details:
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Languages: eng Pagination: 318-21 Citation Subset: IM |
Affiliation:
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School of Pharmacy, Kitasato University, Shirokane, Tokyo, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Aorta, Thoracic / pathology Atherosclerosis / pathology, prevention & control* Blood Glucose / metabolism Body Weight / drug effects Cholesterol / blood Cholesterol, Dietary / toxicity Coenzyme A Ligases / antagonists & inhibitors* Enzyme Inhibitors / pharmacology* Fatty Acids, Nonesterified / blood Mice Mice, Knockout Myocardium / pathology Receptors, LDL / genetics Streptomyces / chemistry, metabolism Triazenes / isolation & purification, pharmacology* Triglycerides / blood |
| Chemical | |
Reg. No./Substance:
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0/Blood Glucose; 0/Cholesterol, Dietary; 0/Enzyme Inhibitors; 0/Fatty Acids, Nonesterified; 0/Receptors, LDL; 0/Triazenes; 0/Triglycerides; 57-88-5/Cholesterol; 76896-80-5/triacsin C; EC 6.2.1.-/Coenzyme A Ligases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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