| Anti-atherogenic property of ferulic acid in apolipoprotein E-deficient mice fed Western diet: comparison with clofibrate. | |
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MedLine Citation:
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PMID: 20573577 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Anti-atherogenic effect of ferulic acid (0.02%, w/w) was investigated in comparison with the clofibrate (0.02%, w/w) in apolipoprotein E-deficient (apo E(-/-)) mice fed Western diet. Concentrations of total cholesterol (total-C), apolipoprotein B (apo B) in the plasma and epididymal adipose tissue weight were significantly lower in the ferulic acid and clofibrate supplemented groups compared to the control group. The ratio of apo B to apo A-I was also significantly lower in those groups than in the control group. Activities of hepatic ACAT and HMG-CoA reductase were only significantly lower in the ferulic acid and clofibrate groups, respectively than in the control group. The numbers of mice that exhibited aortic fatty plaque were 8/10 in control groups vs. 0/10 in the ferulic acid or clofibrate group. The activities of anti-oxidant enzymes (superoxide dismutase, catalase, glutathione peroxidase, glutathione reductase and paraoxonase) in the hepatocyte and erythrocyte were significantly higher in the ferulic acid group than in the control group. In contrast, hepatic TBARS level was only markedly lower in the ferulic acid group. These results provide a new insight into the anti-atherogenic property of ferulic acid in the apo E(-/-) mice fed a Western diet. |
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Authors:
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E Y Kwon; G M Do; Y Y Cho; Y B Park; S M Jeon; M S Choi |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-05-26 |
Journal Detail:
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Title: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association Volume: 48 ISSN: 1873-6351 ISO Abbreviation: Food Chem. Toxicol. Publication Date: 2010 Aug-Sep |
Date Detail:
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Created Date: 2010-07-26 Completed Date: 2010-11-03 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8207483 Medline TA: Food Chem Toxicol Country: England |
Other Details:
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Languages: eng Pagination: 2298-303 Citation Subset: IM |
Copyright Information:
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Copyright (c) 2010 Elsevier Ltd. All rights reserved. |
Affiliation:
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Department of Food Science and Nutrition, Center for Food and Nutritional Genomics, Kyungpook National University, Daegu 702-701, South Korea. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adipose Tissue
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drug effects Animals Anticholesteremic Agents / pharmacology* Antioxidants / pharmacology Apolipoproteins E / genetics*, physiology Aryldialkylphosphatase / metabolism Atherosclerosis / pathology, prevention & control* Clofibrate / pharmacology* Coumaric Acids / pharmacology* Diet* Eating / drug effects Hydroxymethylglutaryl CoA Reductases / metabolism Lipid Peroxidation / drug effects Lipids / blood Male Mice Mice, Inbred C57BL Mice, Knockout Organ Size / drug effects Sterol O-Acyltransferase / metabolism Weight Gain / drug effects |
| Chemical | |
Reg. No./Substance:
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0/Anticholesteremic Agents; 0/Antioxidants; 0/Apolipoproteins E; 0/Coumaric Acids; 0/Lipids; 1135-24-6/ferulic acid; 637-07-0/Clofibrate; EC 1.1.1.-/Hydroxymethylglutaryl CoA Reductases; EC 2.3.1.26/Sterol O-Acyltransferase; EC 3.1.8.1/Aryldialkylphosphatase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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