| Anti-asthmatic activities in mycelial extract and culture filtrate of Cordyceps sphecocephala J201. | |
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MedLine Citation:
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PMID: 20664950 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This study investigated the effects of mycelial extract and culture filtrate of Cordyceps sphecocephala J201 on airway hyper-responsiveness, pulmonary immune cell infiltration, and Th2 cytokine expression in animal models of asthma. After Concanavalin A (Con A) activation of mouse primary spleen cells, the IL-4 and IL-13 cytokine expression were significantly decreased in the presence of the mycelial extract and culture filtrate of Cordyceps sphecocephala J201. The asthma model was induced by sensitization to ovalbumin by intraperitoneal (i.p.) injection treatment in mice. The Cordyceps sphecocephala J201 mycelial extract was injected in order to assess the effects of anti-asthmatic activity by comparing lung cell infiltration in ovalbumin-induced asthmatic mice. The results revealed that the increased IL-4, IL-13 and IL-25 expression were controlled by the mycelial extract and culture filtrate of Cordyceps sphecocephala J201, indicating that the extracts reduced the undesirable immune responses and/or cytokine expression exhibited in asthma. |
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Authors:
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Jin-Chul Heo; Sung-Hee Nam; Dong-Yoon Nam; Jong-Guk Kim; Kwang-Gil Lee; Joo-Hong Yeo; Cheol-Sik Yoon; Chul-Hong Park; Sang-Han Lee |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: International journal of molecular medicine Volume: 26 ISSN: 1791-244X ISO Abbreviation: Int. J. Mol. Med. Publication Date: 2010 Sep |
Date Detail:
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Created Date: 2010-07-28 Completed Date: 2010-11-04 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9810955 Medline TA: Int J Mol Med Country: Greece |
Other Details:
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Languages: eng Pagination: 351-6 Citation Subset: IM |
Affiliation:
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Food & Bio-Industry Research Institute, Kyungpook National University, Daegu, Korea. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Anti-Asthmatic Agents / isolation & purification*, pharmacology, therapeutic use Asthma / drug therapy, immunology Bronchial Hyperreactivity / immunology Cell Line / drug effects Cordyceps / chemistry*, cytology Cytokines / immunology Disease Models, Animal Lung / cytology, drug effects Male Medicine, East Asian Traditional Mice Mice, Inbred BALB C Mice, Inbred C57BL Mycelium / chemistry*, ultrastructure Ovalbumin / immunology Spleen / cytology |
| Chemical | |
Reg. No./Substance:
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0/Anti-Asthmatic Agents; 0/Cytokines; 9006-59-1/Ovalbumin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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