| Anti-arrhythmic efficacy of beta-adrenergic blockade during acute ischemia in myocardium with scar. | |
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MedLine Citation:
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PMID: 7909195 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Ventricular arrhythmia production in the ischemic heart is considered to be influenced by prior infarction. Although beta-adrenergic blockade is known to have beneficial effects during acute ischemia, its anti-arrhythmic efficacy during post-infarction ischemia is not known. To explore this question, we have used a model with a relatively high incidence of ischemic arrhythmias. Mongrel dogs 2 to 3 years of age were studied intact under anesthesia. An irreversible injury of the infero-posterior myocardium was produced with an electrode catheter 1 week earlier. The arrhythmic response to acute ischemia was assessed using serial, transient 15-minute occlusions of the left-anterior descending coronary artery with a balloon catheter. During ischemia alone, the incidence of ventricular fibrillation in animals who underwent all phases of the study was 6 of 9; with atenolol (0.2 mg/kg intravenously) and ischemia, 1 of 9 (p < 0.05). To assess the role of the bradycardic response, the latter was repeated 1 week subsequently during atrial pacing at the heart rate that existed before ischemia. Fibrillation occurred in 8 of 9, a significant reversal of the therapeutic effect. To exclude the potential artifact of a fixed intervention protocol, a study was undertaken with the short-acting esmolol, in which three ischemic periods were alternated at 1-hour intervals: (A) ischemia without treatment, (B) ischemia with continuous infusion of 150 micrograms/kg/min esmolol, and (C) same as B except that heart rate was maintained by atrial pacing.(ABSTRACT TRUNCATED AT 250 WORDS) |
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Authors:
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J Patel; W Lee; L Fusilli; T J Regan |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The American journal of the medical sciences Volume: 307 ISSN: 0002-9629 ISO Abbreviation: Am. J. Med. Sci. Publication Date: 1994 Apr |
Date Detail:
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Created Date: 1994-05-17 Completed Date: 1994-05-17 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0370506 Medline TA: Am J Med Sci Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 259-63 Citation Subset: AIM; IM |
Affiliation:
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Department of Medicine, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark 07103-2714. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adrenergic beta-Antagonists
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therapeutic use* Animals Atenolol / therapeutic use* Blood Pressure / drug effects Disease Models, Animal Dogs Heart Rate / drug effects Male Myocardial Infarction / complications* Myocardial Ischemia / complications* Propanolamines / therapeutic use* Ventricular Fibrillation / etiology, prevention & control* |
| Chemical | |
Reg. No./Substance:
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0/Adrenergic beta-Antagonists; 0/Propanolamines; 29122-68-7/Atenolol; 84057-94-3/esmolol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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