| Anti-arrhythmic effects of sophoridine and oxysophoridine. | |
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MedLine Citation:
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PMID: 10678144 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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AIM: To compare the effects of oxysophoridine (Oxy) and sophoridine (Sop) on experimental arrhythmias and myocardial physiologic properties. METHODS: Arrhythmias were induced by drugs and myocardial ischemia. Physiologic properties were determined on isolated heart atria. RESULTS: Oxy 500 mg.kg-1 (1/6 LD50) decreased the incidence of ventricular arrhythmias induced by aconitine (P < 0.01), increased the threshold dose of ouabain-induced ventricular premature (VP, P < 0.05), ventricular tachycardia (VT, P < 0.05), ventricular fibrillation (VF, P < 0.01), and cardiac arrest, (P < 0.01). After i.v. Oxy 500 mg.kg-1 into the rats with ligation of left anterior descending coronary artery, the total numbers of ectopic beats were decreased (P < 0.05), the incidence of VF was lowered, and the duration of VT was shortened (P < 0.01). Oxy 250 mg.kg-1 (1/13 LD50) i.v. shortened the duration of arrhythmias induced by BaCl2 (P < 0.01) and delayed the onset of arrhythmias induced by chloroform-epinephrine (P < 0.05). Oxy produced dose-dependent positive inotropic effects in the isolated left atrial of guinea pigs, increased the concentration of epinephrine to elicit automaticity in left atria, decreased slightly the excitability, and prolonged the functional refractory period. Sop produced the similar effects on arrhythmias as Oxy. CONCLUSION: Oxy produced the similar anti-arrhythmic effects as Sop did at the equivalent effective dose. |
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Authors:
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H M Zhang; H Q Li |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Zhongguo yao li xue bao = Acta pharmacologica Sinica Volume: 20 ISSN: 0253-9756 ISO Abbreviation: Zhongguo Yao Li Xue Bao Publication Date: 1999 Jun |
Date Detail:
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Created Date: 2000-05-01 Completed Date: 2000-05-01 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8100330 Medline TA: Zhongguo Yao Li Xue Bao Country: CHINA |
Other Details:
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Languages: eng Pagination: 517-20 Citation Subset: IM |
Affiliation:
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Department of Pharmacology, Ningxia Medical College, Yinchuan, China. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aconitine Alkaloids / pharmacology* Animals Anti-Arrhythmia Agents / pharmacology* Arrhythmias, Cardiac / chemically induced, physiopathology* Barium Compounds Chlorides Female Guinea Pigs Heart Arrest / chemically induced, physiopathology Male Mice Myocardial Contraction / drug effects Myocardial Ischemia / chemically induced, physiopathology Ouabain Quinolizines Rabbits Rats Rats, Wistar Refractory Period, Electrophysiological / drug effects |
| Chemical | |
Reg. No./Substance:
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0/Alkaloids; 0/Anti-Arrhythmia Agents; 0/Barium Compounds; 0/Chlorides; 0/Quinolizines; 0/oxysophoridine; 10361-37-2/barium chloride; 302-27-2/Aconitine; 519-02-8/matrine; 630-60-4/Ouabain |
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