Document Detail

Anti-arrhythmic effects of sophoridine and oxysophoridine.
MedLine Citation:
PMID:  10678144     Owner:  NLM     Status:  MEDLINE    
AIM: To compare the effects of oxysophoridine (Oxy) and sophoridine (Sop) on experimental arrhythmias and myocardial physiologic properties. METHODS: Arrhythmias were induced by drugs and myocardial ischemia. Physiologic properties were determined on isolated heart atria. RESULTS: Oxy 500 (1/6 LD50) decreased the incidence of ventricular arrhythmias induced by aconitine (P < 0.01), increased the threshold dose of ouabain-induced ventricular premature (VP, P < 0.05), ventricular tachycardia (VT, P < 0.05), ventricular fibrillation (VF, P < 0.01), and cardiac arrest, (P < 0.01). After i.v. Oxy 500 into the rats with ligation of left anterior descending coronary artery, the total numbers of ectopic beats were decreased (P < 0.05), the incidence of VF was lowered, and the duration of VT was shortened (P < 0.01). Oxy 250 (1/13 LD50) i.v. shortened the duration of arrhythmias induced by BaCl2 (P < 0.01) and delayed the onset of arrhythmias induced by chloroform-epinephrine (P < 0.05). Oxy produced dose-dependent positive inotropic effects in the isolated left atrial of guinea pigs, increased the concentration of epinephrine to elicit automaticity in left atria, decreased slightly the excitability, and prolonged the functional refractory period. Sop produced the similar effects on arrhythmias as Oxy. CONCLUSION: Oxy produced the similar anti-arrhythmic effects as Sop did at the equivalent effective dose.
H M Zhang; H Q Li
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Zhongguo yao li xue bao = Acta pharmacologica Sinica     Volume:  20     ISSN:  0253-9756     ISO Abbreviation:  Zhongguo Yao Li Xue Bao     Publication Date:  1999 Jun 
Date Detail:
Created Date:  2000-05-01     Completed Date:  2000-05-01     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8100330     Medline TA:  Zhongguo Yao Li Xue Bao     Country:  CHINA    
Other Details:
Languages:  eng     Pagination:  517-20     Citation Subset:  IM    
Department of Pharmacology, Ningxia Medical College, Yinchuan, China.
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MeSH Terms
Alkaloids / pharmacology*
Anti-Arrhythmia Agents / pharmacology*
Arrhythmias, Cardiac / chemically induced,  physiopathology*
Barium Compounds
Guinea Pigs
Heart Arrest / chemically induced,  physiopathology
Myocardial Contraction / drug effects
Myocardial Ischemia / chemically induced,  physiopathology
Rats, Wistar
Refractory Period, Electrophysiological / drug effects
Reg. No./Substance:
0/Alkaloids; 0/Anti-Arrhythmia Agents; 0/Barium Compounds; 0/Chlorides; 0/Quinolizines; 0/oxysophoridine; 10361-37-2/barium chloride; 302-27-2/Aconitine; 519-02-8/matrine; 630-60-4/Ouabain

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