Document Detail


Anti-apoptotic versus pro-apoptotic signal transduction: checkpoints and stop signs along the road to death.
MedLine Citation:
PMID:  9779994     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The activation of caspases is a final commitment step for apoptosis. It is now evident that signal transduction pathways involving specific protein kinases modulate the apoptotic response. Both pro-apoptotic and anti-apoptotic pathways integrate environmental cues that control the decision to undergo apoptosis. Pro- and anti-apoptotic signal pathways regulate the activation of the caspases. In this review we describe our current understanding of apoptotic signal transduction.
Authors:
M B Jarpe; C Widmann; C Knall; T K Schlesinger; S Gibson; T Yujiri; G R Fanger; E W Gelfand; G L Johnson
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Oncogene     Volume:  17     ISSN:  0950-9232     ISO Abbreviation:  Oncogene     Publication Date:  1998 Sep 
Date Detail:
Created Date:  1998-11-23     Completed Date:  1998-11-23     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  8711562     Medline TA:  Oncogene     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  1475-82     Citation Subset:  IM    
Affiliation:
Program in Molecular Signal Transduction, Division of Basic Sciences, National Jewish Medical and Research Center, Denver, Colorado 80206, USA.
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MeSH Terms
Descriptor/Qualifier:
1-Phosphatidylinositol 3-Kinase / metabolism
Animals
Apoptosis / physiology*
Caspases / metabolism
Cytokines / metabolism
Growth Substances / metabolism
Humans
MAP Kinase Kinase 3
Mitogen-Activated Protein Kinase Kinases*
Protein-Serine-Threonine Kinases / metabolism
Protein-Tyrosine Kinases / metabolism
Proto-Oncogene Proteins c-bcl-2 / genetics,  metabolism
Signal Transduction*
Chemical
Reg. No./Substance:
0/Cytokines; 0/Growth Substances; 0/Proto-Oncogene Proteins c-bcl-2; EC 2.7.1.-/MAP2K3 protein, human; EC 2.7.1.137/1-Phosphatidylinositol 3-Kinase; EC 2.7.10.1/Protein-Tyrosine Kinases; EC 2.7.11.1/Protein-Serine-Threonine Kinases; EC 2.7.12.2/MAP Kinase Kinase 3; EC 2.7.12.2/Mitogen-Activated Protein Kinase Kinases; EC 3.4.22.-/Caspases

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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