| Anti-apoptotic protein TCTP controls the stability of the tumor suppressor p53. | |
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MedLine Citation:
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PMID: 21081126 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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In this study, we identified p53 as a novel TCTP-interacting protein using TCTP as bait. Also, we determined the critical binding sites between TCTP and p53. To elucidate the functional consequence of the interaction, we developed the overexpression and inhibition system of TCTP and p53 expression. Overexpression of TCTP in lung carcinoma cells reversed p53 mediated apoptosis and inhibition of TCTP expression by small interfering RNA increased apoptosis of lung carcinoma cells. Moreover, it was observed that TCTP overexpression promotes degradation of p53. These results clearly indicate that the interaction between TCTP and p53 prevents apoptosis by destabilizing p53. Thus, TCTP acts as a negative regulator of apoptosis in lung cancer. |
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Authors:
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Seung Bae Rho; Jeong Heon Lee; Mi Sun Park; Hyun-Jung Byun; Sokbom Kang; Sang-Soo Seo; Joo-Young Kim; Sang-Yoon Park |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-11-17 |
Journal Detail:
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Title: FEBS letters Volume: 585 ISSN: 1873-3468 ISO Abbreviation: FEBS Lett. Publication Date: 2011 Jan |
Date Detail:
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Created Date: 2011-01-07 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0155157 Medline TA: FEBS Lett Country: Netherlands |
Other Details:
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Languages: eng Pagination: 29-35 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved. |
Affiliation:
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Research Institute, National Cancer Center, Ilsandong-gu, Goyang-si Gyeonggi-do, Republic of Korea. sbrho@ncc.re.kr |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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