| Anti-apoptotic effect of trans-resveratrol on paclitaxel-induced apoptosis in the human neuroblastoma SH-SY5Y cell line. | |
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MedLine Citation:
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PMID: 11278107 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Paclitaxel, an anticancer drug, induces apoptosis in human neuroblastoma cell line SH-SY5Y. The addition of trans-resveratrol, a natural antioxidant present in grapes and red wine, to SH-SY5Y cultures exposed to paclitaxel significantly reduces cellular death. The neuroprotective action of trans-resveratrol is due neither to its antioxidant capacity nor to interference with the polymerization of tubulin induced by paclitaxel. However, trans-resveratrol is able to inhibit the activation of caspase 7 and degradation of poly-(ADP-ribose)-polymerase which occur in SH-SY5Y exposed to paclitaxel. Resveratrol, therefore, exerts its anti-apoptotic effect by modulating the signal pathways that commit these neuronal-like cells to apoptosis. |
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Authors:
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G Nicolini; R Rigolio; M Miloso; A A Bertelli; G Tredici |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Neuroscience letters Volume: 302 ISSN: 0304-3940 ISO Abbreviation: Neurosci. Lett. Publication Date: 2001 Apr |
Date Detail:
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Created Date: 2001-03-30 Completed Date: 2001-06-14 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7600130 Medline TA: Neurosci Lett Country: Ireland |
Other Details:
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Languages: eng Pagination: 41-4 Citation Subset: IM |
Affiliation:
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Dipartimento di Neuroscienze e Tecnologie Biomediche, Università degli Studi di Milano-Bicocca, Via Cadore, 48, 20052, Monza, Italy. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Antineoplastic Agents, Phytogenic
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pharmacology Antioxidants / pharmacology* Apoptosis / drug effects*, physiology Caspase 7 Caspases / drug effects*, metabolism Humans Neuroblastoma / metabolism*, pathology Paclitaxel / pharmacology Stilbenes / pharmacology* Tumor Cells, Cultured / drug effects |
| Chemical | |
Reg. No./Substance:
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0/Antineoplastic Agents, Phytogenic; 0/Antioxidants; 0/Stilbenes; 33069-62-4/Paclitaxel; 501-36-0/resveratrol; EC 3.4.22.-/CASP7 protein, human; EC 3.4.22.-/Caspase 7; EC 3.4.22.-/Caspases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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