| Anti-apoptotic and Pro-survival Effects of Exercise Training on Hypertensive Hearts. | |
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MedLine Citation:
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PMID: 22207725 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Background. Activated cardiac apoptosis was found in hearts from hypertensive animals but less information regarding the effects of exercise training on cardiac apoptosis in hypertension is available. The purpose of this study was to evaluate the anti-apoptotic and pro-survival effects of exercise training on hypertensive hearts. Methods. Twenty-eight spontaneously hypertensive rats were divided into sedentary group (SHR) or underwent running exercise on treadmill for 1 hour per day, 5 sections per week, for 12 weeks (SHR-EX). Fourteen age-matched Wistar Kyoto rats served as a sedentary normotensive group (WKY). After exercise training or sedentary status, the excised hearts were measured by H&E staining, TUNEL assay and Western Blotting. Results. TUNEL-positive apoptotic cells became less in SHR-EX groups than those in SHR. Protein levels of Fas ligand, Fas death receptor, TNF-α, TNF receptor 1, Fas-associated death domain (FADD), activated caspase-8, and activated caspase-3 (Fas-dependent apoptotic pathways), as well as Bid, t-Bid, Bad, p-Bad, Bak, cytochrome c, activated caspase 9 and activated caspase-3 (mitochondria-dependent apoptotic pathways) were decreased in SHR-EX group compared with SHR group. Protein levels of IGF1, IGF1R, p-PI3K, p-Akt, p-Bad, and Bcl2 (cardiac pro-survival pathway) become more activated in SHR-EX groups than SHR and WKY. Conclusions. Exercise training prevented hypertension-enhanced cardiac Fas-dependent and mitochondria-dependent apoptotic pathways and enhanced cardiac pro-survival pathway in rat models. Our findings demonstrate new therapeutic effects of exercise training on hypertensive hearts for preventing apoptosis and enhancing survival. |
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Authors:
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Chih-Yang Huang; Ai-Lun Yang; Yueh-Min Lin; Fen-Ni Wu; James A Lin; Yi-Sheng Chan; Fu-Zen Tsai; Chang-Hai Tsai; Chia-Hua Kuo; Shin-Da Lee |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-12-29 |
Journal Detail:
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Title: Journal of applied physiology (Bethesda, Md. : 1985) Volume: - ISSN: 1522-1601 ISO Abbreviation: - Publication Date: 2011 Dec |
Date Detail:
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Created Date: 2011-12-30 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8502536 Medline TA: J Appl Physiol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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1China Medical University. |
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