| Anti-angiogenic effects of liposomal prednisolone phosphate on B16 melanoma in mice. | |
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MedLine Citation:
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PMID: 16707187 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Prednisolone phosphate (PLP) encapsulated in long-circulating liposomes can inhibit tumor growth after intravenous administration (i.v.). These antitumor effects of liposomal PLP are the result of the tumor-targeting property of the liposome formulation. The mechanism by which liposomal PLP inhibits tumor growth is unclear. We investigated the effects of liposome-encapsulated PLP versus free PLP on angiogenic protein production in tumor tissue in vivo and on viability and proliferation of tumor and endothelial cells in vitro. In vivo, liposomal PLP had a stronger reducing effect on pro-angiogenic protein levels than free PLP, whereas levels of anti-angiogenic proteins were hardly affected. Cell viability was only slightly affected with either treatment. Liposomal PLP had strong anti-proliferative effects on human umbilical vein endothelial cells, whereas free PLP had hardly any effect. Taken together, the present study points to a strong inhibitory effect of liposomal PLP on tumor angiogenesis by reduction of the intratumoral production of the majority of pro-angiogenic factors studied and direct inhibition of endothelial cell proliferation, which is the result of high prolonged levels of prednisolone in the tumor by liposomal delivery. |
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Authors:
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Manuela Banciu; Raymond M Schiffelers; Marcel H A M Fens; Josbert M Metselaar; Gert Storm |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't Date: 2006-04-07 |
Journal Detail:
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Title: Journal of controlled release : official journal of the Controlled Release Society Volume: 113 ISSN: 0168-3659 ISO Abbreviation: J Control Release Publication Date: 2006 Jun |
Date Detail:
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Created Date: 2006-06-12 Completed Date: 2006-08-25 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8607908 Medline TA: J Control Release Country: Netherlands |
Other Details:
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Languages: eng Pagination: 1-8 Citation Subset: IM |
Affiliation:
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Department of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences (UIPS), Utrecht University, Utrecht, The Netherlands. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cell Line, Tumor Cell Proliferation / drug effects Cell Survival / drug effects Cells, Cultured Colonic Neoplasms / drug therapy, metabolism, pathology, prevention & control Drug Delivery Systems Endothelium, Vascular / drug effects Humans Injections, Intravenous Liposomes* Male Melanoma, Experimental / blood supply*, pathology, prevention & control* Mice Mice, Inbred C57BL Neovascularization, Pathologic / prevention & control* Prednisolone / administration & dosage, analogs & derivatives*, therapeutic use Time Factors Umbilical Veins / cytology |
| Chemical | |
Reg. No./Substance:
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0/Liposomes; 302-25-0/prednisolone phosphate; 50-24-8/Prednisolone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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