| Anti-angiogenic effects of betulinic acid Administered in nanoemulsion formulation Using chorioallantoic membrane assay. | |
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MedLine Citation:
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PMID: 21702370 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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Betulinic acid (3beta, hydroxy-lup-20(29)-en-28-oic acid, BA), a pentacyclic triterpenoid, is derived from a widely distributed natural anticancer compound betulin. It has selective anticancer activity against several tumor cells, and recently it was shown that it also possess anti-angiogenic effects. The objective of this study was to formulate betulinic acid, a poorly aqueous-soluble compound, in flax-seed oil containing nanoemulsion formulation for enhanced delivery efficiency and to effectively inhibit the tumor angiogenic process. The nanoemulsion was prepared using high pressure homogenization method with a Microfludizer processor. The betulinic acid nanoemulsion was studied for the effect on the angiogenic process by performing the in vivo chick embryo chorioallantoic membrane (CAM) assay. The sample volume of 1 microl and 5 microl of the blank and BA nanoemulsions were applied directly on the CAM. The preliminary results from macroscopic, morphological and immunohistochemical evaluations have shown that morphological change was produced in the CAM mesenchyme with a negative impact on the normal growth of the capillaries. Betulinic acid does possess anti-angiogenic activity in a dose dependent manner, and the nanoemulsion formulation maintained this effect. |
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Authors:
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Cristina A Dehelean; Stefana Feflea; Srinivas Ganta; Mansoor Amiji |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of biomedical nanotechnology Volume: 7 ISSN: 1550-7033 ISO Abbreviation: J Biomed Nanotechnol Publication Date: 2011 Apr |
Date Detail:
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Created Date: 2011-06-27 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101230869 Medline TA: J Biomed Nanotechnol Country: United States |
Other Details:
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Languages: eng Pagination: 317-24 Citation Subset: IM |
Affiliation:
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Toxicology Department, University of Medicine and Pharmacy Victor Babes Timisoara, Eftimie Murgu Square, No. 2, Timisoara, 300041, Romania. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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