Document Detail


Anti-angiogenic activity of ursodeoxycholic acid and its derivatives.
MedLine Citation:
PMID:  9065810     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Ursodeoxycholic acid (UDCA) and its derivatives were examined for anti-angiogenic activities by using the chick embryo chorioallantoic membrane (CAM) assay. The presence of UDCA or its derivatives inhibited angiogenesis in a dose-dependent manner; the dose required for half-maximal inhibition (ID50) was 4 microg per CAM for UDCA. The conjugate forms of UDCA with glycine methyl ester (HS-1030), L-leucine benzyl ester (HS-1068) and L-leucine methyl ester (HS-1133) were showing ID50 of 0.09, 0.08 and 0.6 microg per CAM, respectively. Also, the effect of UDCA and its derivatives on the viability of calf pulmonary artery endothelial (CPAE) cells was examined. Among them, HS-1030 effectively reduced the viability of CPAE cells in a concentration-dependent manner. Based on these results, we speculated that HS-1030 might be a promising candidate as angiogenesis inhibitor for use in the management of diseases accompanied by uncontrolled angiogenesis including solid tumor.
Authors:
H Suh; E J Jung; T H Kim; H Y Lee; Y H Park; K W Kim
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Cancer letters     Volume:  113     ISSN:  0304-3835     ISO Abbreviation:  Cancer Lett.     Publication Date:  1997 Feb 
Date Detail:
Created Date:  1997-04-07     Completed Date:  1997-04-07     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7600053     Medline TA:  Cancer Lett     Country:  IRELAND    
Other Details:
Languages:  eng     Pagination:  117-22     Citation Subset:  IM    
Affiliation:
Department of Chemistry, Pusan National University, South Korea.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Cattle
Cell Survival / drug effects
Cells, Cultured
Chick Embryo
Endothelium, Vascular / drug effects
Extraembryonic Membranes / drug effects
Neovascularization, Physiologic / drug effects*
Pulmonary Artery / drug effects
Ursodeoxycholic Acid / analogs & derivatives,  pharmacology*
Chemical
Reg. No./Substance:
128-13-2/Ursodeoxycholic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  In vitro effect of gallium nitrate when combined with ketoconazole in the prostate cancer cell line ...
Next Document:  Cyclin D1 (PRAD1) alternative transcript b: full-length cDNA cloning and expression in breast cancer...