Document Detail


Anti-allergic properties of Cissampelos sympodialis and its isolated alkaloid warifteine.
MedLine Citation:
PMID:  16714219     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Development of new agents capable of regulating eosinophilic inflammation can uncover novel therapeutic approaches for the treatment of allergic diseases, such as asthma. Here, we evaluated the anti-allergic properties of an extract of the Brazilian Menispermaceae Cissampelos sympodialis, focusing on its effects on allergic eosinophilia. By studying two models of allergic inflammation, an asthma model and the allergic pleurisy in actively sensitized Balb/c mice, we observed that the oral pre-treatment with C. sympodialis reduced pleural eosinophil influx triggered by allergen challenge in a dose-dependent manner. The mechanism involved in C. sympodialis inhibitory effect appeared to be independent of a direct effect on eosinophil locomotory machinery, but depend on a blockage of eotaxin production, a key eosinophil chemoattractant with important roles in allergic reactions. C. sympodialis was also able to affect eosinophil activation, as attested by its ability of inhibiting formation of new cytoplasmic lipid bodies and the secretion of cysteinyl leukotrienes. The alkaloid warifteine isolated from the C. sympodialis extract represents an active component responsible for the anti-eosinophilic effects of the extract, since warifteine was able to reproduce C. sympodialis inhibitory effects on allergic eosinophilia and cysteinyl leukotrienes production. Of interest, C. sympodialis and warifteine post-treatments also effectively inhibited eosinophilic reaction observed after allergic challenge. Therefore, C. sympodialis/warifteine may be a promising anti-allergic therapy, inasmuch as it presents potent anti-eosinophil and anti-leukotrienes activities.
Authors:
Cláudio R Bezerra-Santos; Adriana Vieira-de-Abreu; José Maria Barbosa-Filho; Christianne Bandeira-Melo; Marcia R Piuvezam; Patrícia T Bozza
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2006-03-06
Journal Detail:
Title:  International immunopharmacology     Volume:  6     ISSN:  1567-5769     ISO Abbreviation:  Int. Immunopharmacol.     Publication Date:  2006 Jul 
Date Detail:
Created Date:  2006-05-22     Completed Date:  2006-09-01     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  100965259     Medline TA:  Int Immunopharmacol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  1152-60     Citation Subset:  IM    
Affiliation:
Laboratório de Tecnologia Farmacêutica, Departamento de Fisiologia e Patologia, Universidade Federal da Paraíba, João Pessoa, 58051-970, Paraíba, Brazil.
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MeSH Terms
Descriptor/Qualifier:
Alkaloids / pharmacology*
Allergens / pharmacology
Animals
Anti-Allergic Agents / pharmacology*
Asthma / drug therapy*
Bronchoalveolar Lavage Fluid / chemistry,  cytology
Cells, Cultured
Chemokine CCL11
Chemokines, CC / analysis
Cissampelos / chemistry*
Disease Models, Animal
Eosinophils / drug effects,  immunology
Female
Humans
Leukocyte Count
Leukotrienes / analysis
Male
Mice
Mice, Inbred BALB C
Ovalbumin / pharmacology
Plant Extracts / pharmacology
Plant Leaves / chemistry
Pleurisy / drug therapy*
Pulmonary Eosinophilia / drug therapy
Grant Support
ID/Acronym/Agency:
TW05890/TW/FIC NIH HHS
Chemical
Reg. No./Substance:
0/Alkaloids; 0/Allergens; 0/Anti-Allergic Agents; 0/CCL11 protein, human; 0/Ccl11 protein, mouse; 0/Chemokine CCL11; 0/Chemokines, CC; 0/Leukotrienes; 0/Plant Extracts; 38566-54-0/warifteine; 9006-59-1/Ovalbumin

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