| Anti-allergic prenylated flavonoids from the roots of Sophora flavescens. | |
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MedLine Citation:
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PMID: 18219599 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The bioassay-guided fractionation of the MeOH extract from the root of Sophora flavescens led to the isolation of eight known prenylated flavonoids ( 1 - 8) responsible for the IN VITRO anti-allergic activity. Among them, kushenol N ( 3), sophoraflavanone G ( 6), and leachianone A ( 7) demonstrated significant inhibition of the release of beta-hexosaminidase from cultured RBL-2H3 cells with IC (50) values ranging from 15 to 30 muM. |
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Authors:
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Wenying Quan; Hee Ju Lee; Chul Young Kim; Chu Won Noh; Byung Hun Um; Min-Ho Oak; Kyeong-Man Kim |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2008-01-24 |
Journal Detail:
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Title: Planta medica Volume: 74 ISSN: 0032-0943 ISO Abbreviation: Planta Med. Publication Date: 2008 Feb |
Date Detail:
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Created Date: 2008-02-20 Completed Date: 2008-05-21 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0066751 Medline TA: Planta Med Country: Germany |
Other Details:
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Languages: eng Pagination: 168-70 Citation Subset: IM |
Affiliation:
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Department of Pharmacology, Drug Development Research Center, College of Pharmacy, Chonnam National University, Kwang-Ju, Korea. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Anti-Allergic Agents / isolation & purification, pharmacology* Cell Line, Tumor Flavonoids / isolation & purification, pharmacology* Leukemia, Basophilic, Acute Plant Roots / chemistry* Rats Sophora / chemistry* beta-N-Acetylhexosaminidases / antagonists & inhibitors, metabolism |
| Chemical | |
Reg. No./Substance:
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0/Anti-Allergic Agents; 0/Flavonoids; EC 3.2.1.52/beta-N-Acetylhexosaminidases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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