Document Detail


Anti-allergic prenylated flavonoids from the roots of Sophora flavescens.
MedLine Citation:
PMID:  18219599     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The bioassay-guided fractionation of the MeOH extract from the root of Sophora flavescens led to the isolation of eight known prenylated flavonoids ( 1 - 8) responsible for the IN VITRO anti-allergic activity. Among them, kushenol N ( 3), sophoraflavanone G ( 6), and leachianone A ( 7) demonstrated significant inhibition of the release of beta-hexosaminidase from cultured RBL-2H3 cells with IC (50) values ranging from 15 to 30 muM.
Authors:
Wenying Quan; Hee Ju Lee; Chul Young Kim; Chu Won Noh; Byung Hun Um; Min-Ho Oak; Kyeong-Man Kim
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-01-24
Journal Detail:
Title:  Planta medica     Volume:  74     ISSN:  0032-0943     ISO Abbreviation:  Planta Med.     Publication Date:  2008 Feb 
Date Detail:
Created Date:  2008-02-20     Completed Date:  2008-05-21     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0066751     Medline TA:  Planta Med     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  168-70     Citation Subset:  IM    
Affiliation:
Department of Pharmacology, Drug Development Research Center, College of Pharmacy, Chonnam National University, Kwang-Ju, Korea.
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MeSH Terms
Descriptor/Qualifier:
Animals
Anti-Allergic Agents / isolation & purification,  pharmacology*
Cell Line, Tumor
Flavonoids / isolation & purification,  pharmacology*
Leukemia, Basophilic, Acute
Plant Roots / chemistry*
Rats
Sophora / chemistry*
beta-N-Acetylhexosaminidases / antagonists & inhibitors,  metabolism
Chemical
Reg. No./Substance:
0/Anti-Allergic Agents; 0/Flavonoids; EC 3.2.1.52/beta-N-Acetylhexosaminidases

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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