| Anti-allergic effect of lambertianic acid from Thuja orientalis in mouse bone marrow-derived mast cells. | |
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MedLine Citation:
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PMID: 21854102 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Lambertianic acid is a bioactive diterpene found in the leaves of Thuja orientalis. Its effect on the bone marrow-derived mast cell (BMMC) mediated allergy and inflammation mechanism remains unknown. In this study, lambertianic acid was evaluated for its effect on the allergic mediators, including prostaglandin D(2) (PGD(2)), leukotriene C(4) (LTC(4)), β-hexosaminidase (β-Hex) and cyclooxygenase-2 (COX-2) protein, in phorbol 12-myristate 13-acetate (PMA) plus calcimycin-stimulated BMMCs. The results revealed that lambertianic acid inhibited the production of interleukin-6 (IL-6), PGD(2) and LTC(4), the expression of COX-2 and the degranulation of β-hexosaminidase in the PMA plus calcimycin-induced BMMCs. Taken together, these findings implied that lambertianic acid may possess the potential in the treatment of allergy. |
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Authors:
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Hee-Sung Chae; Young-Won Chin |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-8-19 |
Journal Detail:
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Title: Immunopharmacology and immunotoxicology Volume: - ISSN: 1532-2513 ISO Abbreviation: - Publication Date: 2011 Aug |
Date Detail:
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Created Date: 2011-8-22 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8800150 Medline TA: Immunopharmacol Immunotoxicol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Immune Modulator Research Center, Bio-Therapeutics Research Institute, Korea Research Institute of Bioscience & Biotechnology , Korea. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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