| Anti-aging effects of cyanidin under a stress-induced premature senescence cellular system. | |
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MedLine Citation:
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PMID: 20190403 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The anti-aging effects of cyanidin were investigated under stress-induced premature senescence (SIPS) using WI-38 human diploid fibroblasts. WI-38 cells that were treated with 300 microM H(2)O(2) showed losses of cell viability, increased lipid peroxidation, and shortened cell lifespans. However, treatment with cyanidin attenuated cellular oxidative stress through increase of cell viability and the inhibition of lipid peroxidation. In addition, the life spans of young-, middle-, and old-aged WI-38 cells were prolonged by cyanidin treatment. Furthermore, H(2)O(2)-treated WI-38 cells significantly increased mRNA and protein expressions of nuclear factor-kappaB, cyclooxygenase-2, and inducible nitric oxide synthase, while those treated with cyanidin had significantly decreased expressions. These results suggest that cyanidin may delay the aging process by attenuating oxidative stress under the SIPS cellular model. |
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Authors:
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Mi Jin Choi; Boh Kyung Kim; Kun Young Park; Takako Yokozawa; Young Ok Song; Eun Ju Cho |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Biological & pharmaceutical bulletin Volume: 33 ISSN: 1347-5215 ISO Abbreviation: Biol. Pharm. Bull. Publication Date: 2010 |
Date Detail:
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Created Date: 2010-03-01 Completed Date: 2010-09-20 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9311984 Medline TA: Biol Pharm Bull Country: Japan |
Other Details:
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Languages: eng Pagination: 421-6 Citation Subset: IM |
Affiliation:
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Department of Food Science and Nutrition, Research Institute of Ecology for the Elderly, Pusan National University, Jangjeon-dong, Geumjeong-gu, Busan 609-735, Korea. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Anthocyanins
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pharmacology* Antioxidants / pharmacology* Cell Aging / drug effects*, physiology Cell Survival / drug effects* Cyclooxygenase 2 / genetics, metabolism Fibroblasts / drug effects* Humans Hydrogen Peroxide Lipid Peroxidation / drug effects NF-kappa B / genetics, metabolism Nitric Oxide Synthase Type II / genetics, metabolism Oxidative Stress / drug effects* Plant Extracts / pharmacology* RNA, Messenger / metabolism |
| Chemical | |
Reg. No./Substance:
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0/Anthocyanins; 0/Antioxidants; 0/NF-kappa B; 0/Plant Extracts; 0/RNA, Messenger; 13306-05-3/cyanidin; 7722-84-1/Hydrogen Peroxide; EC 1.14.13.39/Nitric Oxide Synthase Type II; EC 1.14.99.1/Cyclooxygenase 2 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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