Document Detail

Anti-acne effects of Oriental herb extracts: a novel screening method to select anti-acne agents.
MedLine Citation:
PMID:  12637783     Owner:  NLM     Status:  MEDLINE    
The acne-therapeutic effects of Oriental herb extracts were investigated in terms of antichemotactic effect on polymorphonuclear leucocytes, antilipogenic actions, antibacterial activity against Propionibacterium acnes and resistance induction potency in the bacteria. The ethanol extract (0.01%) of Angelica dahurica markedly suppressed neutrophil chemotaxis, comparable to the effect of erythromycin (0.01%), whereas a strong antilipogenic effect was obtained with rhizoma coptidis (Coptis chinensis) extract (0.01%), leading to a higher efficacy than that of retinoic acid (0.01%). Interestingly, only Glycyrrhiza glabra showed a remarkable antibacterial activity against P. acnes, resulting in negligible induction of resistance, in comparison with a marked development of resistance in the bacteria treated with erythromycin. We suggest that an appropriate formulation containing A. dahurica, rhizoma coptidis and G. glabra could be helpful for the prevention and treatment of acne lesions.
C Nam; S Kim; Y Sim; I Chang
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Skin pharmacology and applied skin physiology     Volume:  16     ISSN:  1422-2868     ISO Abbreviation:  Skin Pharmacol. Appl. Skin Physiol.     Publication Date:    2003 Mar-Apr
Date Detail:
Created Date:  2003-03-14     Completed Date:  2003-11-12     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9807277     Medline TA:  Skin Pharmacol Appl Skin Physiol     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  84-90     Citation Subset:  IM    
Copyright Information:
Copyright 2003 S. Karger AG, Basel
Skin Reserach Institute, Pacific R&D Center, Yongin, Korea.
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MeSH Terms
Acne Vulgaris / drug therapy*
Angelica / chemistry
Anti-Bacterial Agents / isolation & purification,  pharmacology,  therapeutic use*
Arctium / chemistry
Cells, Cultured
Drug Resistance, Microbial
Drugs, Chinese Herbal / isolation & purification,  pharmacology,  therapeutic use*
Erythromycin / pharmacology,  therapeutic use
Glycyrrhiza / chemistry
Microbial Sensitivity Tests
Neutrophils / drug effects
Reg. No./Substance:
0/Anti-Bacterial Agents; 0/Drugs, Chinese Herbal; 114-07-8/Erythromycin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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