Document Detail


Anti-Yo mediated paraneoplastic cerebellar degeneration in the context of breast cancer: a case report and literature review.
MedLine Citation:
PMID:  23585287     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
BACKGROUND: Paraneoplastic syndromes are of interest to psycho-oncologists because they may be misdiagnosed initially as primary psychiatric disorders and can have profound neuropsychiatric and psychosocial sequelae. Paraneoplastic cerebellar degeneration (PCD) is a paraneoplastic syndrome which destroys Purkinje cells of the cerebellum and causes trunk and limb ataxia, dysarthria, diplopia, and vertigo, which often precede the diagnosis of cancer. Anti-Yo PCD is a devastating syndrome that significantly worsens prognosis in terms of functional ability and survival. METHODS: We present the case of a woman with progressive cerebellar deficits, which were misdiagnosed for several months before breast cancer and anti-Yo antibodies were discovered. RESULTS: PCD may be misdiagnosed as a primary psychiatric disorder. Results of neuropsychological assessment in this case found subtle attentional dysfunction but relatively preserved cognitive functioning in other domains. DISCUSSION: The literature relating to PCD and psychiatric manifestations of cerebellar disease are reviewed. The limitations of our current understanding of non-motor cerebellar function are highlighted, asserting the need for further study in this area. Copyright © 2013 John Wiley & Sons, Ltd.
Authors:
Richard Garrett Key; James C Root
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-4-14
Journal Detail:
Title:  Psycho-oncology     Volume:  -     ISSN:  1099-1611     ISO Abbreviation:  Psychooncology     Publication Date:  2013 Apr 
Date Detail:
Created Date:  2013-4-15     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9214524     Medline TA:  Psychooncology     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2013 John Wiley & Sons, Ltd.
Affiliation:
Memorial Sloan-Kettering Cancer Center, Psychiatry and Behavioral Sciences, New York, NY, USA.
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