| Anti-U3 RNP autoantibodies in systemic sclerosis. | |
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MedLine Citation:
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PMID: 19333934 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To describe the classification, demographic and clinical features, and survival in anti-U3 RNP autoantibody-positive patients with systemic sclerosis (SSc). METHODS: Medical records of 108 anti-U3 RNP-positive and 2,471 anti-U3 RNP-negative SSc patients first evaluated during 1985-2003 were reviewed. Anti-U3 RNP antibody was detected by protein and RNA immunoprecipitation. Disease classification, demographic and clinical features, organ system involvement, and survival were compared between the 2 patient groups, by Student's t-test, chi-square analysis, and Mantel-Haenszel test. RESULTS: The anti-U3 RNP-positive group had a higher proportion of African American patients (27% versus 5%; P < 0.001) and male patients (29% versus 19%; P = 0.021), and was younger at the time of first physician diagnosis (mean age 42.8 years versus 47.4 years; P = 0.001). The 2 groups had similar proportions of patients with diffuse cutaneous involvement (47% and 45% in those with and those without anti-U3 RNP, respectively). However, among patients with diffuse cutaneous involvement, the mean maximum modified Rodnan skin score was significantly lower in the anti-U3 RNP group (22.3 versus 27.9; P < 0.001). Skeletal muscle involvement was more frequent in anti-U3 RNP-positive patients (25% versus 14%; P = 0.002), as was "intrinsic" pulmonary arterial hypertension (PAH) (31% versus 13%; P < 0.001). The frequency of gastrointestinal involvement, cardiac involvement, pulmonary fibrosis, and "renal crisis" did not differ significantly between the 2 groups. Survival was worse in the anti-U3 RNP-positive group (hazard ratio 1.38 [95% confidence interval 1.05-1.82]). PAH was the most common known cause of death in patients with anti-U3 RNP (30%, versus 10% in the anti-U3 RNP-negative group; P < 0.001). CONCLUSION: The present findings demonstrate that the frequencies of African American race and male sex are greater among SSc patients with anti-U3 RNP antibody than those without, and the former group is younger at SSc diagnosis. Anti-U3 RNP-positive patients have more frequent skeletal muscle involvement and PAH, the latter being the most common cause of death. |
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Authors:
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Rohit Aggarwal; Mary Lucas; Noreen Fertig; Chester V Oddis; Thomas A Medsger |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Arthritis and rheumatism Volume: 60 ISSN: 0004-3591 ISO Abbreviation: Arthritis Rheum. Publication Date: 2009 Apr |
Date Detail:
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Created Date: 2009-04-07 Completed Date: 2009-06-22 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0370605 Medline TA: Arthritis Rheum Country: United States |
Other Details:
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Languages: eng Pagination: 1112-8 Citation Subset: AIM; IM |
Affiliation:
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University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult African Americans / statistics & numerical data* Autoantibodies / blood* European Continental Ancestry Group / statistics & numerical data* Female Gastrointestinal Diseases / ethnology, immunology, mortality Heart Diseases / ethnology, immunology, mortality Humans Hypertension, Pulmonary / ethnology, immunology, mortality Male Middle Aged Pulmonary Fibrosis / ethnology, immunology, mortality Ribonucleoproteins, Small Nucleolar / immunology* Scleroderma, Systemic / ethnology*, immunology*, mortality Seroepidemiologic Studies Sex Distribution Skin Diseases / ethnology, immunology, mortality Survival Analysis |
| Chemical | |
Reg. No./Substance:
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0/Autoantibodies; 0/Ribonucleoproteins, Small Nucleolar; 0/ribonucleoprotein, U3 small nucleolar |
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