| Anti-Tac (daclizumab, Zenapax) in the treatment of leukemia, autoimmune diseases, and in the prevention of allograft rejection: a 25-year personal odyssey. | |
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MedLine Citation:
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PMID: 17216565 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Twenty-five years ago, we reported the production of the monoclonal antibody, anti-Tac that identifies the IL-2 receptor alpha subunit and blocks the interaction of IL-2 with this growth factor receptor. In 1997, daclizumab (Zenapax), the humanized form of this antibody, was approved by the FDA for use in the prevention of renal allograft rejection. In addition, we demonstrated that daclizumab is of value in the treatment of patients with noninfectious uveitis, multiple sclerosis, and the neurological disease human T-cell lymphotropic virus I associated myelopathy/tropical spastic paraparesis (HAM/TSP). Others demonstrated therapeutic efficacy with daclizumab in patients with pure red cell aplasia, aplastic anemia, and psoriasis. Thus, translation of basic insights concerning the IL-2/IL-2 receptor system obtained using the monoclonal antibody daclizumab provided a useful strategy for the prevention of organ allograft rejection and the treatment of patients with select autoimmune diseases or T-cell leukemia/lymphoma. |
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Authors:
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Thomas A Waldmann |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Intramural; Review Date: 2007-01-11 |
Journal Detail:
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Title: Journal of clinical immunology Volume: 27 ISSN: 0271-9142 ISO Abbreviation: J. Clin. Immunol. Publication Date: 2007 Jan |
Date Detail:
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Created Date: 2007-02-08 Completed Date: 2007-05-08 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8102137 Medline TA: J Clin Immunol Country: United States |
Other Details:
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Languages: eng Pagination: 1-18 Citation Subset: IM |
Affiliation:
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Metabolism Branch, Center for Cancer Research, National Cancer Institute, NIH Building 10, Bethesda, Maryland 20892-1374, USA. tawald@helix.nih.gov |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antibodies, Monoclonal / immunology, pharmacology, therapeutic use* Autoimmune Diseases / drug therapy* Binding, Competitive / immunology Graft Rejection / immunology, prevention & control* Humans Immunoglobulin G / immunology, pharmacology, therapeutic use* Immunosuppressive Agents / therapeutic use* Interleukin-2 / antagonists & inhibitors, immunology Interleukin-2 Receptor alpha Subunit / antagonists & inhibitors, immunology Leukemia / drug therapy*, metabolism Leukemia-Lymphoma, Adult T-Cell / drug therapy Mice Paraparesis, Tropical Spastic / drug therapy Receptors, Interleukin-2 / antagonists & inhibitors, drug effects*, immunology Uveitis / drug therapy |
| Chemical | |
Reg. No./Substance:
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0/Antibodies, Monoclonal; 0/Immunoglobulin G; 0/Immunosuppressive Agents; 0/Interleukin-2; 0/Interleukin-2 Receptor alpha Subunit; 0/Receptors, Interleukin-2; 152923-56-3/daclizumab |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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