Document Detail


Anti-TNF therapy induced immune neutropenia in Crohns disease- report of 2 cases and review of literature.
MedLine Citation:
PMID:  22398078     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Transient neutropenia is reported in some patients on biologic therapy. We report two cases of severe neutropenia in patients with Crohn`s disease following treatment with anti-TNF therapy. In both cases neutrophil specific granulocyte autoantibodies were detected during period of neutropenia and disappeared on cessation of anti-TNF therapy. These may indicate that anti-TNF agents may produce autoimmune agranulocytosis by triggering production granulocyte autoantibodies. The long term management strategy for patients with anti-TNF therapy induced autoimmune neutropenia is uncertain.
Authors:
Shaji Sebastian; Katherine Ashton; Yasmine Houston; Tina Mary Diggory; Philip Dore
Related Documents :
10589298 - Understanding the effects of extrinsic rewards on intrinsic motivation--uses and abuses...
1934558 - The effect of intensity on combined glottography.
24270678 - Resolution of conjunctival sessile hemangioma with topical timolol.
19021688 - Utility of software analysis of esophageal manometry studies in patients with aperistal...
18479628 - Making the most of your pathology: standardized histopathology reporting in head and ne...
894828 - Association of transverse testicular ectopia and seminal vesicle cyst.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-2-24
Journal Detail:
Title:  Journal of Crohn's & colitis     Volume:  -     ISSN:  1876-4479     ISO Abbreviation:  -     Publication Date:  2012 Feb 
Date Detail:
Created Date:  2012-3-8     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101318676     Medline TA:  J Crohns Colitis     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012 European Crohn's and Colitis Organisation. Published by Elsevier B.V. All rights reserved.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Development of a numerical index quantitating small bowel damage as detected by ultrasonography in C...
Next Document:  Enteroendocrine cells in terminal ileal Crohn's disease.