| Anti-TNF therapy induced immune neutropenia in Crohns disease- report of 2 cases and review of literature. | |
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MedLine Citation:
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PMID: 22398078 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Transient neutropenia is reported in some patients on biologic therapy. We report two cases of severe neutropenia in patients with Crohn`s disease following treatment with anti-TNF therapy. In both cases neutrophil specific granulocyte autoantibodies were detected during period of neutropenia and disappeared on cessation of anti-TNF therapy. These may indicate that anti-TNF agents may produce autoimmune agranulocytosis by triggering production granulocyte autoantibodies. The long term management strategy for patients with anti-TNF therapy induced autoimmune neutropenia is uncertain. |
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Authors:
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Shaji Sebastian; Katherine Ashton; Yasmine Houston; Tina Mary Diggory; Philip Dore |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-2-24 |
Journal Detail:
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Title: Journal of Crohn's & colitis Volume: - ISSN: 1876-4479 ISO Abbreviation: - Publication Date: 2012 Feb |
Date Detail:
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Created Date: 2012-3-8 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101318676 Medline TA: J Crohns Colitis Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2012 European Crohn's and Colitis Organisation. Published by Elsevier B.V. All rights reserved. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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