| Anti-TNFα therapy early improves hemodynamics in local intestinal and extraintestinal circulations in active Crohn's disease. | |
| | |
MedLine Citation:
|
PMID: 22841134 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
BACKGROUND AND AIMS: Active Crohn's disease affects intestine but may alter other locations as eyes vasculature. Previous studies provide evidence of elevated blood flow velocities (BFv) and volume (BFV) in superior mesenteric artery (SMA). We prospectively studied hemodynamics in feeding arteries of bowel and eyes before and 2weeks after treatment induction with anti-TNFα. METHODS: Fifteen patients (5 females, 10 males, 35.4±9.0years, mean±SD) with active Crohn's disease for 7.5±7.7years were enrolled. Ultrasound imaging was performed before and 2weeks after treatment in SMA and retrobulbar arteries: central retinal (CRA), temporal posterior ciliary (TPCA) and ophthalmic (OA) arteries. Serum markers of inflammation (CRP and fibrinogen), arterial blood pressures (ABP) and skin flow-mediated dilation (sFMD) were measured and patients were compared to 10 control age- and sex-matched subjects. RESULTS: Before treatment, CRP and fibrinogen plasma concentrations, SMA BFV (339±100mL/min) were higher in patients than in controls by 8.5-fold (p<0.001), 1.4-fold (p<0.01) and 1.5-fold, respectively (p<0.01). BFv in CRA (3.5±0.7cm/s) and TPCA (4.4±1.0cm/s), sFMD (371±469%) were significantly lower than in controls by 83%, 73% and 52% respectively (p<0.05). Two weeks after treatment, CRP and fibrinogen decreased, SMA BFV was normalized (230±39L/min, p<0.01), BFv in CRA, TPCA and OA increased respectively to 4.0±1.1 (p<0.05), 5.2±1.4 (p<0.001), 8.9±3cm/s (p<0.05). ABP and sFMD remained unchanged. CONCLUSIONS: In active Crohn's disease, a first anti-TNFα administration rapidly normalized concomitantly plasma inflammatory markers and blood-flows in the mesenteric and retrobulbar arteries without affecting blood pressure and endothelial function. |
| | |
Authors:
|
Philippe Bonnin; Jessica Coelho; Marc Pocard; Bernard I Levy; Philippe Marteau |
Related Documents
:
|
16197934 - Quantitative determination of guanidinoacetate and creatine in dried blood spot by flow... 626334 - Blood microfiltration. a review. 16926074 - An experimental/computational approach for examining unconfined cohesive powder flow. 7264434 - Effect of blood transfusion on in vivo levels of plasma fibronectin. 16721024 - Continuous flow peritoneal dialysis: current state-of-the-art and obstacles to further ... 6881544 - Changes in the endothelial morphology of the developing semilunar heart valves. a tem a... |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2012-7-26 |
Journal Detail:
|
Title: Journal of Crohn's & colitis Volume: - ISSN: 1876-4479 ISO Abbreviation: - Publication Date: 2012 Jul |
Date Detail:
|
Created Date: 2012-7-30 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 101318676 Medline TA: J Crohns Colitis Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
|
Copyright © 2012 European Crohn's and Colitis Organisation. Published by Elsevier B.V. All rights reserved. |
Affiliation:
|
Univ Paris Diderot, Sorbonne Paris Cité, AP-HP, Hôpital Lariboisière, Physiologie Clinique-Explorations-Fonctionnelles, 75010, Paris, France; Univ Paris Diderot, Sorbonne Paris Cité, INSERM, U965, 75010, Paris, France. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Mercaptopurine-induced hepatoportal sclerosis in a patient with Crohn's disease.
Next Document: A simplified clustering method for novice narcotic chemists.