Document Detail


Anti-TNF agents in familial Mediterranean fever: report of three cases and review of the literature.
MedLine Citation:
PMID:  21567247     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Familial Mediterranean fever (FMF) is an autoinflammatory disease characterized by recurrent fever, peritonitis/pleuritis, or arthritis attacks. Patients may have FMF-associated mutations of pyrin. The role of biologics such as anti-tumor necrosis factor (TNF) agents (infliximab, etanercept, adalimumab, golimumab) and anakinra, canakinumab, or rilonacept in the treatment of FMF needs to be clarified. Herein we present reports of three patients (all were positive for HLA B27) with typical spondylitis associated with FMF who were successfully managed with anti-TNF agents, along with a literature review. The patients were a 37-year-old man with concomitant Crohn's disease and amyloidosis who was treated with infliximab (INF, 5 mg/kg for 3 years) and switched to adalimumab (ADA), and two female patients (a 24-year-old and a 31-year-old) with FMF who developed severe spondylitis and who were also treated with ADA. Anti-TNF agents can control FMF attacks quite effectively and they reveal a promising role in the treatment of FMF-associated amyloidosis and spondylitis.
Authors:
Salih Ozgocmen; Ozgur Akgul
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Publication Detail:
Type:  Case Reports; Journal Article; Review     Date:  2011-05-13
Journal Detail:
Title:  Modern rheumatology / the Japan Rheumatism Association     Volume:  21     ISSN:  1439-7609     ISO Abbreviation:  Mod Rheumatol     Publication Date:  2011 Dec 
Date Detail:
Created Date:  2011-12-14     Completed Date:  2012-07-19     Revised Date:  2013-05-27    
Medline Journal Info:
Nlm Unique ID:  100959226     Medline TA:  Mod Rheumatol     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  684-90     Citation Subset:  IM    
Affiliation:
Division of Rheumatology, Dept. PMR, Gevher Nesibe Hospital, Erciyes University, School of Medicine, 38039 Kayseri, Turkey. sozgocmen@hotmail.com
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MeSH Terms
Descriptor/Qualifier:
Adult
Anti-Inflammatory Agents / therapeutic use*
Antibodies, Monoclonal / therapeutic use*
Antibodies, Monoclonal, Humanized / therapeutic use*
Familial Mediterranean Fever / drug therapy*
Female
Humans
Male
Treatment Outcome
Tumor Necrosis Factor-alpha / antagonists & inhibitors*
Chemical
Reg. No./Substance:
0/Anti-Inflammatory Agents; 0/Antibodies, Monoclonal; 0/Antibodies, Monoclonal, Humanized; 0/Tumor Necrosis Factor-alpha; 0/infliximab; FYS6T7F842/adalimumab

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