| Anti-SOX1 antibodies in patients with paraneoplastic and non-paraneoplastic neuropathy. | |
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MedLine Citation:
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PMID: 20701982 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Anti-SOX1 antibodies have been described to be positive in patients with paraneoplastic Lambert-Eaton myasthenic syndrome and, in a lower amount, in patients with anti-Hu positive paraneoplastic neurological syndromes, and with SCLC alone, respectively. We found 5/32 patients with paraneoplastic neuropathy and, surprisingly, 4/22 patients with neuropathy of unknown origin positive for anti-SOX1 antibodies, whereas no patient with inflammatory neuropathy and no healthy controls showed any reactivity (p=0.007). All patients with neuropathy of unknown origin where followed up for four years without diagnosis of a tumour so far. Anti-SOX1 antibodies are associated with paraneoplastic neuropathies and may define another group of non-paraneoplastic, immune-mediated neuropathies. |
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Authors:
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M Tschernatsch; P Singh; O Gross; T Gerriets; N Kneifel; C Probst; S Malas; M Kaps; F Blaes |
Publication Detail:
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Type: Journal Article Date: 2010-08-11 |
Journal Detail:
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Title: Journal of neuroimmunology Volume: 226 ISSN: 1872-8421 ISO Abbreviation: J. Neuroimmunol. Publication Date: 2010 Sep |
Date Detail:
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Created Date: 2010-09-10 Completed Date: 2010-10-06 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8109498 Medline TA: J Neuroimmunol Country: Netherlands |
Other Details:
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Languages: eng Pagination: 177-80 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 Elsevier B.V. All rights reserved. |
Affiliation:
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Dept. of Neurology, Justus-Liebig-University, Am Steg 14, 35385 Giessen, Germany. Marlene.Tschernatsch@neuro.med.uni-giessen.de |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Aged, 80 and over Animals Autoantibodies / metabolism* Cell Line, Transformed Female Hu Paraneoplastic Encephalomyelitis Antigens / immunology Humans Lambert-Eaton Myasthenic Syndrome / immunology*, metabolism Male Mice Middle Aged Paraneoplastic Polyneuropathy / immunology*, metabolism Paraneoplastic Syndromes, Nervous System / classification, immunology, metabolism SOXB1 Transcription Factors / immunology* Transfection / methods |
| Chemical | |
Reg. No./Substance:
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0/Autoantibodies; 0/Hu Paraneoplastic Encephalomyelitis Antigens; 0/SOXB1 Transcription Factors |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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