| Anti-Ro (SSA) and anti-La (SSB) antibodies and complete congenital heart block. | |
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MedLine Citation:
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PMID: 9255327 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Complete congenital heart block (CCHB) is the most severe manifestation of neonatal lupus syndrome, associated with a mortality rate of up to 31%. It is caused by irreversible damage to the cardiac conduction system due to the transplacental passage of maternal antibodies to the fetus. Anti-Ro (SSA) and anti-La (SSB) antibodies are usually detected in sera of mothers of children with prenatally diagnosed CCHB and in cardiac tissues of affected newborns. Their pathogeneic role in the development of CCHB has been established in several studies. When CCHB is detected during pregnancy, careful monitoring and delivery are needed before heart failure is developed. Treatment strategies are debatable and may include prophylactic therapy for high-risk pregnant women and a combination of intrauterine plasmapheresis with plasma exchange or with corticosteroids. Pacemaker insertion is required in most infants during the first three months of life. Assays for anti-Ro (SSA) and anti-La (SSB) antibodies should be performed on sera of pregnant women with SLE and newborns with CCHB. |
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Authors:
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Y Finkelstein; Y Adler; L Harel; M Nussinovitch; P Youinou |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Annales de médecine interne Volume: 148 ISSN: 0003-410X ISO Abbreviation: Ann Med Interne (Paris) Publication Date: 1997 |
Date Detail:
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Created Date: 1997-09-02 Completed Date: 1997-09-02 Revised Date: 2005-11-16 |
Medline Journal Info:
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Nlm Unique ID: 0171744 Medline TA: Ann Med Interne (Paris) Country: FRANCE |
Other Details:
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Languages: eng Pagination: 205-8 Citation Subset: IM |
Affiliation:
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Department of Pediatrics C Schneider Children's Medical Center of Israel, Petah Tikvah, Israel. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Antibodies
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analysis* Female Fetal Diseases / immunology, therapy Heart Block / congenital*, immunology, therapy Humans Infant, Newborn Lupus Erythematosus, Systemic / immunology Pregnancy Pregnancy Complications / immunology Ribonucleoproteins / immunology* |
| Chemical | |
Reg. No./Substance:
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0/Antibodies; 0/Ribonucleoproteins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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